genové interakce a polygenní dědičnost</titl= e>  <link rel=3DPresentation-XML href=3D"interakcepolygenprakt_soubory/pres.xml= "> <meta name=3DDescription content=3D"4.12.2009: INTERAKCE NEALELNÍCH GENŮ POLYGENN&Iacu= te; DĚDIČNOST "> <meta http-equiv=3Dexpires content=3D0> <![if !ppt]><script>  </script> <![endif]> </head> <body> <script></script><font face=3DArial size=3D2><b> <p>Obsah této prezentace pravděpodobně nebude prohlížeč schopen správně zobrazit.</p> <p>Chcete-li i přesto pokračovat, klepněte <a href=3D"interakcepolygenprakt_soubory/frame.htm">sem</a>.</p> </b></font><script></script> </body> </html> ------=_NextPart_01CA753A.A0BCA130 Content-Location: file:///C:/D13A91D4/interakcepolygenprakt_soubory/master03.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" 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xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 12"> <link id=3DMain-File rel=3DMain-File href=3D"../interakcepolygenprakt.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>genové interakce a polygenní dědičnost</titl= e> <![if IE]> <base href=3D"file:///C:\D13A91D4\interakcepolygenprakt_soubory\slide0004.h= tm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"4.12.2009: Krátké opakov&= aacute;ní:"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"4"/> </o:shapelayout> </head> <body lang=3DCS style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:#FFCCFF;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000000,#808080,#000000,#bbe0e3,#333399,#009999,#99cc00" masterhref=3D"master03.xml"> <v:background id=3D"_x0000_s4097" o:bwmode=3D"white" fillcolor=3D"#fcf"> <v:fill color2=3D"#339 [5]"/> </v:background><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1028= "/><p:shaperange href=3D"master03.xml#_x0000_s1029"/><![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s4098" type=3D"= #_x0000_m1026" style=3D'position:absolute;left:36pt;top:54.5pt;width:9in;height:72.625pt; visibility:visible;mso-wrap-style:square;v-text-anchor:middle'> <v:stroke o:forcedash=3D"f"/> <v:path arrowok=3D"f"/> <o:lock v:ext=3D"edit" rotation=3D"f" aspectratio=3D"f" position=3D"f" se= lection=3D"f" verticies=3D"f" text=3D"f" adjusthandles=3D"f" grouping=3D"t" shapetype= =3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate-with-shape:t' inset= =3D"7.2pt,3.6pt,7.2pt,3.6pt"/> <p:placeholder type=3D"title" position=3D"-1"/></v:shape><p:shaperange href=3D"master03.xml#_x0000_m1027"/><v:shape id=3D"_x0000_s4099" type=3D"= #_x0000_m1027" style=3D'position:absolute;left:36pt;top:156.625pt;width:9in;height:357.1= 25pt; visibility:visible;mso-wrap-style:square;v-text-anchor:top'> <v:stroke o:forcedash=3D"f"/> <v:path arrowok=3D"f"/> <o:lock v:ext=3D"edit" rotation=3D"f" aspectratio=3D"f" position=3D"f" se= lection=3D"f" verticies=3D"f" text=3D"f" adjusthandles=3D"f" grouping=3D"t" shapetype= =3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate-with-shape:t' inset= =3D"7.2pt,3.6pt,7.2pt,3.6pt"/> <p:placeholder type=3D"body" position=3D"-1"/></v:shape> <div v:shape=3D"_x0000_s4098" class=3DT style=3D'text-align:left;mso-char-= wrap:1; mso-kinsoku-overflow:1;position:absolute;top:12.5%;left:5.99%;width:88.2%; height:9.25%'><b>Krátké opakování:</b></div> <div v:shape=3D"_x0000_s4099"> <div class=3DB style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:30.0%;left:5.99%;width:88.2%;height:6.75%'><span style=3D'position:abs= olute; top:0%;left:4.24%;width:95.75%;height:100.0%'><span style=3D'mso-special-f= ormat: bullet;position:absolute;left:-4.43%'>•</span><b>Jednotková dědičnost </b></span></div> <div class=3DB1 style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1'><span style=3D'position:absolute;top:38.5%;left:14.04%;width:92.69%;height:6.0%'= ><span style=3D'mso-special-format:bullet;position:absolute;left:-3.23%'>–<= /span><b>podíl alel téhož genu (lokusu) při utváření = </b></span><span style=3D'position:absolute;top:44.5%;left:14.04%;width:79.96%;height:6.0%'= ><b>fenotypu hybrida </b></span></div> <div class=3DB1 style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:a= bsolute; top:52.0%;left:11.04%;width:83.14%;height:6.0%'><span style=3D'position:ab= solute; top:0%;left:3.6%;width:96.17%;height:100.0%'><span style=3D'mso-special-fo= rmat: bullet;position:absolute;left:-3.74%'>–</span><b>rozdíly ve stupni dominance alel </b></span></div> <div class=3DB style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:59.75%;left:5.99%;width:88.2%;height:6.75%'><span style=3D'position:ab= solute; top:0%;left:4.24%;width:95.75%;height:100.0%'><span style=3D'mso-special-f= ormat: bullet;position:absolute;left:-4.43%'>•</span><b>Alelní a nealelní geny </b></span></div> <div class=3DB style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:68.25%;left:5.99%;width:88.2%;height:6.75%'><span style=3D'position:ab= solute; top:0%;left:4.24%;width:95.75%;height:100.0%'><span style=3D'mso-special-f= ormat: bullet;position:absolute;left:-4.43%'>•</span><b>Dihybridismus <= /b></span></div> <div class=3DB1 style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:a= bsolute; top:76.5%;left:11.04%;width:97.56%;height:6.0%'><span style=3D'position:ab= solute; top:0%;left:3.07%;width:96.92%;height:100.0%'><span style=3D'mso-special-f= ormat: bullet;position:absolute;left:-3.16%'>–</span><b>16tipolní tabulka genotypových kombinací </b></span></div> <div class=3DB1 style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:a= bsolute; top:84.0%;left:11.04%;width:95.5%;height:6.0%'><span style=3D'position:abs= olute; top:0%;left:3.13%;width:96.86%;height:100.0%'><span style=3D'mso-special-f= ormat: bullet;position:absolute;left:-3.23%'>–</span><b>genotypové a fenotypové štěpné poměry. </b></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01CA753A.A0BCA130 Content-Location: file:///C:/D13A91D4/interakcepolygenprakt_soubory/slide0005.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 12"> <link id=3DMain-File rel=3DMain-File href=3D"../interakcepolygenprakt.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>genové interakce a polygenní dědičnost</titl= e> <![if IE]> <base href=3D"file:///C:\D13A91D4\interakcepolygenprakt_soubory\slide0005.h= tm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"4.12.2009: Úvod I:"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"5"/> </o:shapelayout> </head> <body lang=3DCS style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:#CCFFCC;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000000,#808080,#000000,#bbe0e3,#333399,#009999,#99cc00" masterhref=3D"master03.xml"> <v:background id=3D"_x0000_s5121" o:bwmode=3D"white" fillcolor=3D"#cfc"> <v:fill color2=3D"#339 [5]"/> </v:background><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1028= "/><p:shaperange href=3D"master03.xml#_x0000_s1029"/><![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s5122" type=3D"= #_x0000_m1026" style=3D'position:absolute;left:36pt;top:14.875pt;width:9in;height:44.25p= t; visibility:visible;mso-wrap-style:square;v-text-anchor:middle'> <v:stroke o:forcedash=3D"f"/> <v:path arrowok=3D"f"/> <o:lock v:ext=3D"edit" rotation=3D"f" aspectratio=3D"f" position=3D"f" se= lection=3D"f" verticies=3D"f" text=3D"f" adjusthandles=3D"f" grouping=3D"t" shapetype= =3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate-with-shape:t' inset= =3D"7.2pt,3.6pt,7.2pt,3.6pt"/> <p:placeholder type=3D"title" position=3D"-1"/></v:shape><p:shaperange href=3D"master03.xml#_x0000_m1027"/><v:shape id=3D"_x0000_s5123" type=3D"= #_x0000_m1027" style=3D'position:absolute;left:19.75pt;top:60.25pt;width:686.125pt;heigh= t:464.875pt; visibility:visible;mso-wrap-style:square;v-text-anchor:top'> <v:stroke o:forcedash=3D"f"/> <v:path arrowok=3D"f"/> <o:lock v:ext=3D"edit" rotation=3D"f" aspectratio=3D"f" position=3D"f" se= lection=3D"f" verticies=3D"f" text=3D"f" adjusthandles=3D"f" grouping=3D"t" shapetype= =3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate-with-shape:t' inset= =3D"7.2pt,3.6pt,7.2pt,3.6pt"/> <p:placeholder type=3D"body" position=3D"-1"/></v:shape> <div v:shape=3D"_x0000_s5122" class=3DT style=3D'mso-char-wrap:1;mso-kinso= ku-overflow: 1;position:absolute;top:3.0%;left:5.99%;width:88.2%;height:8.5%'><span style=3D'font-size:91%'><b>Úvod I:</b></span></div> <div v:shape=3D"_x0000_s5123"> <div class=3DB style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-kin= soku-overflow: 1'><span style=3D'position:absolute;top:11.25%;left:7.49%;width:93.63%; height:6.0%'><span style=3D'font-size:88%'><span style=3D'mso-special-form= at:bullet; position:absolute;left:-4.0%'>•</span></span><span style=3D'font-siz= e: 88%'><b>na genetické determinaci</b></span><span style=3D'font-size= :88%'> určitých znaků </span><span style=3D'font-size:88%'><b>se= </b></span></span><span style=3D'position:absolute;top:16.25%;left:7.49%;width:89.7%;height:6.0%'>= <span style=3D'font-size:88%'><b>spolupodílejí</b></span><span style=3D'font-size:88%'> alely dvou, tří a více genů </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-ki= nsoku-overflow: 1'><span style=3D'position:absolute;top:22.25%;left:11.79%;width:91.57%; height:6.0%'><span style=3D'mso-special-format:bullet;position:absolute; left:-3.27%'>–</span><b>gény modifikátory</b>, <b>modi= fikátorové gény</b> - </span><span style=3D'position:absolute;top:27.25%;left:= 11.79%; width:93.07%;height:6.0%'>určité gény jen pozměňují (modifikují) stupeň </span><span style=3D'position:absolute;top:32.25%;left:11.79%;width:85.39%;height:6.0%= '>projevu jiných nealelních genů </span></div> <div class=3DB1 style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-ki= nsoku-overflow: 1'><span style=3D'position:absolute;top:38.5%;left:11.79%;width:95.31%; height:6.0%'><span style=3D'mso-special-format:bullet;position:absolute; left:-3.14%'>–</span><b>genová interakce </b>- pokud alely určitých genů </span><span style=3D'position:absolute; top:43.5%;left:11.79%;width:102.24%;height:6.0%'>zcela zásadně mění fenotypový účinek alel jiných <= /span><span style=3D'position:absolute;top:48.5%;left:11.79%;width:96.44%;height:6.0%'= >genů, znak vzniká spolupůsobením dvou nebo </span><span style=3D'position:absolute;top:53.5%;left:11.79%;width:85.39%;height:6.0%'= >více nealelních genů </span></div> <div class=3DB style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-kin= soku-overflow: 1'><span style=3D'position:absolute;top:59.75%;left:7.49%;width:89.7%; height:6.0%'><span style=3D'font-size:88%'><span style=3D'mso-special-form= at:bullet; position:absolute;left:-4.17%'>•</span></span><span style=3D'font-si= ze: 88%'><b>geny komplementární, epistatické nebo </b></s= pan></span><span style=3D'position:absolute;top:64.75%;left:7.49%;width:99.25%;height:6.0%'= ><span style=3D'font-size:88%'><b>suplementární</b></span><span style=3D'font-size:88%'> - podle toho, jak rovnoměrně se </span>= </span><span style=3D'position:absolute;top:69.75%;left:7.49%;width:101.12%;height:6.0%= '><span style=3D'font-size:88%'>jednotlivé geny na výsledném fenotypu uplatňují, </span></span><span style=3D'position:abso= lute; top:74.75%;left:7.49%;width:89.7%;height:6.0%'><span style=3D'font-size:88= %'>přehled v tabulkách na str. 47 a 48</span><span style=3D'font-size:88%'><i>= Kot</i></span><span style=3D'font-size:88%'>. </span></span></div> <div class=3DB style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-kin= soku-overflow: 1'><span style=3D'position:absolute;top:80.75%;left:7.49%;width:91.94%; height:6.0%'><span style=3D'font-size:88%'><span style=3D'mso-special-form= at:bullet; position:absolute;left:-4.07%'>•</span></span><span style=3D'font-si= ze: 88%'><b>význam modelových příkladů</b></spa= n><span style=3D'font-size:88%'> z rostlinné a </span></span><span style=3D'position:absolute;top:85.75%;left:7.49%;width:96.06%;height:6.0%'= ><span style=3D'font-size:88%'>zejména savčí genetiky – u člověka je analýza </span></span><span style=3D'position:= absolute; top:90.75%;left:7.49%;width:89.7%;height:6.0%'><span style=3D'font-size:88= %'>situace komplikovanější.</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01CA753A.A0BCA130 Content-Location: file:///C:/D13A91D4/interakcepolygenprakt_soubory/slide0007.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator 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style=3D'mso-margin-left-alt:1008'></div> <div class=3DO4 style=3D'mso-margin-left-alt:1296'></div> <div class=3DO><span style=3D'position:absolute;top:23.75%;left:3.55%;widt= h:52.99%; height:5.75%'><span style=3D'font-family:Verdana;mso-ascii-font-family:Ver= dana; mso-hansi-font-family:Verdana;font-size:133%'>Homozygocie alel jednoho </s= pan></span><span style=3D'position:absolute;top:29.25%;left:3.55%;width:46.06%;height:5.75%= '><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>genu postihuje expresi </span></span><span style=3D'position:absolute;top:34.5%;left:3.55%;width:45.69%;height:5.75%'= ><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>genu druhého</span><span lang=3DEN-US style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>.</span></span></div> </div> <div v:shape=3D"_x0000_s7173"> <div 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<div class=3DO style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:225; mso-char-wrap:1;mso-kinsoku-overflow:1'><span style=3D'position:absolute; top:54.5%;left:7.67%;width:43.82%;height:5.75%'><span style=3D'font-family= :Verdana; font-size:133%'><span style=3D'mso-special-format:bullet;position:absolute; left:-8.97%'>•</span></span><span style=3D'font-family:Verdana;mso-a= scii-font-family: Verdana;mso-hansi-font-family:Verdana;font-size:133%'>Genotyp </span><span lang=3DEN-US style=3D'font-family:Verdana;mso-ascii-font-family:Verdana; mso-hansi-font-family:Verdana;font-size:133%'><i>hh</i></span><span lang=3DEN-US style=3D'font-family:Verdana;mso-ascii-font-family:Verdana; mso-hansi-font-family:Verdana;font-size:133%'> =3D </span><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>netvoří </span></span><span style=3D'position:absolute;top:59.5%;left:7.67%;width:40.26%;height:5.75%'= ><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>se substance </span><span lang=3DEN-US style=3D'fo= nt-family: Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-family:Verdana; font-size:133%'>H.</span><span style=3D'font-family:Verdana;mso-ascii-font= -family: Verdana;mso-hansi-font-family:Verdana;font-size:133%;display:none'> </= span></span></div> <div class=3DO style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:225; mso-char-wrap:1;mso-kinsoku-overflow:1'><span style=3D'position:absolute; top:65.25%;left:7.67%;width:46.44%;height:5.75%'><span style=3D'font-famil= y: Verdana;font-size:133%'><span style=3D'mso-special-format:bullet;position:= absolute; left:-8.46%'>•</span></span><span style=3D'font-family:Verdana;mso-a= scii-font-family: Verdana;mso-hansi-font-family:Verdana;font-size:133%'>Všechny genotypy AB0 </span></span><span style=3D'position:absolute;top:70.0%;left:7.67%; width:44.38%;height:5.75%'><span 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8.5%'><span style=3D'font-size:91%'><b>Úvod II:<br> </b></span></span><span style=3D'position:absolute;top:11.75%;left:.56%; width:99.06%;height:8.5%'><span style=3D'font-size:91%'><b>Rekapitulace základních pojmů</b></span></span></div> <div v:shape=3D"_x0000_s8195" class=3DB> <div style=3D'mso-line-spacing:"90 20 0";mso-char-wrap:1;mso-kinsoku-overf= low: 1;position:absolute;top:26.25%;left:14.79%;width:70.78%;height:6.75%'><span style=3D'position:absolute;top:0%;left:5.29%;width:94.7%;height:100.0%'><s= pan style=3D'mso-special-format:bullet;position:absolute;left:-5.58%'>•<= /span>multifaktoriální znaky </span></div> <div style=3D'mso-line-spacing:"90 20 0";mso-char-wrap:1;mso-kinsoku-overf= low: 1;position:absolute;top:34.25%;left:14.79%;width:70.78%;height:6.75%'><span style=3D'position:absolute;top:0%;left:5.29%;width:94.7%;height:100.0%'><s= pan style=3D'mso-special-format:bullet;position:absolute;left:-5.58%'>•<= /span>polygenní dědičnost </span></div> <div 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arrowok=3D"f"/> <o:lock v:ext=3D"edit" rotation=3D"f" aspectratio=3D"f" position=3D"f" se= lection=3D"f" verticies=3D"f" text=3D"f" adjusthandles=3D"f" grouping=3D"t" shapetype= =3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate-with-shape:t' inset= =3D"7.2pt,3.6pt,7.2pt,3.6pt"/> <p:placeholder type=3D"body" position=3D"-1"/><p:animation number=3D"2" d= elay=3D"0" type=3D"text" level=3D"1" effect=3D"fly" direction=3D"down"/></v:shape> <div v:shape=3D"_x0000_s11266" class=3DB> <div id=3D"_x0000_s11266_0_139" style=3D'mso-line-spacing:"80 20 0";mso-ma= rgin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:9.75%; left:2.8%;width:97.94%;height:14.25%;white-space:nowrap'><span style=3D'position:absolute;top:0%;left:4.39%;width:95.79%;height:40.35%'><= span style=3D'font-family:"Century Gothic";font-size:75%;font-weight:bold'><span style=3D'mso-special-format:"numbullet3\,1";position:absolute;left:-4.59%'= >1.</span></span><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>O multifaktoriální etiologii lze uvažovat, když má </b></span></span><span style=3D'position:absolute;top:29.82%; left:4.39%;width:92.16%;height:40.35%'><span style=3D'font-family:"Century= Gothic"; mso-ascii-font-family:"Century Gothic";mso-hansi-font-family:"Century Goth= ic"; font-size:75%'><b>choroba zjevně familiální výsk= yt, avšak nelze </b></span></span><span style=3D'position:absolute;top:59= .64%; left:4.39%;width:92.16%;height:40.35%'><span style=3D'font-family:"Century= Gothic"; mso-ascii-font-family:"Century Gothic";mso-hansi-font-family:"Century Goth= ic"; font-size:75%'><b>jednoznačně určit typ dědičnost= i v rodině </b></span></span></div> <div id=3D"_x0000_s11266_139_245" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:23.75%; left:2.8%;width:109.17%;height:10.0%;white-space:nowrap'><span style=3D'position:absolute;top:0%;left:3.94%;width:96.22%;height:57.5%'><s= pan style=3D'font-family:"Century Gothic";font-size:75%;font-weight:bold'><span style=3D'mso-special-format:"numbullet3\,1";position:absolute;left:-4.09%'= >2.</span></span><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>Riziko pro příbuzné I. stupně je přibližně odmocninou z </b></span></span><span style=3D'position:absolute;top:42.5%; left:3.94%;width:90.73%;height:57.5%'><span style=3D'font-family:"Century = Gothic"; mso-ascii-font-family:"Century Gothic";mso-hansi-font-family:"Century Goth= ic"; font-size:75%'><b>rizika populačního (incidence) – Edwardsův vzorec </b></span></span></div> <div id=3D"_x0000_s11266_245_343" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:33.25%; left:2.8%;width:102.62%;height:10.0%;white-space:nowrap'><span style=3D'position:absolute;top:0%;left:4.19%;width:95.8%;height:57.5%'><sp= an style=3D'font-family:"Century Gothic";font-size:75%;font-weight:bold'><span style=3D'mso-special-format:"numbullet3\,1";position:absolute;left:-4.38%'= >3.</span></span><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>Riziko je podstatně nižší pro příbuzné II. stupně, pro </b></span></span><span style=3D'position:absolute;top:42= .5%; left:4.19%;width:87.95%;height:57.5%'><span style=3D'font-family:"Century = Gothic"; mso-ascii-font-family:"Century Gothic";mso-hansi-font-family:"Century Goth= ic"; font-size:75%'><b>vzdálenější příbuzné klesá již méně rychle&= #13;</b></span></span></div> <div id=3D"_x0000_s11266_343_484" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:42.75%; left:2.8%;width:111.23%;height:14.25%;white-space:nowrap'><span style=3D'position:absolute;top:0%;left:3.87%;width:96.29%;height:40.35%'><= span style=3D'font-family:"Century Gothic";font-size:75%;font-weight:bold'><span style=3D'mso-special-format:"numbullet3\,1";position:absolute;left:-4.02%'= >4.</span></span><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>Riziko je vyšší, když je postiženo více členů rodiny – pro </b></span></span><span style=3D'positi= on: absolute;top:29.82%;left:3.87%;width:82.82%;height:40.35%'><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>příbu= zné I. stupně se hodnota vypočtená podle </b></span></span><s= pan style=3D'position:absolute;top:59.64%;left:3.87%;width:81.14%;height:40.35= %'><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>Edwardsova vzorce násobí 2, 3 apod. </b></span></span></div> <div id=3D"_x0000_s11266_484_561" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:56.75%; left:2.8%;width:110.86%;height:10.0%;white-space:nowrap'><span style=3D'position:absolute;top:0%;left:3.88%;width:96.11%;height:57.5%'><s= pan style=3D'font-family:"Century Gothic";font-size:75%;font-weight:bold'><span style=3D'mso-special-format:"numbullet3\,1";position:absolute;left:-4.04%'= >5.</span></span><span style=3D'mso-ascii-font-family:"Century Gothic";mso-hansi-font-family:"Cen= tury Gothic"; font-size:75%'><b>Čím těžší je postižení či dřívější manifestace tím vyšší je </b></span></span><span style=3D'position:absolute;top:42.5%;left:3.88%;width:81.41%;height:57.5%'= ><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>riziko opakování </b></span></span></div> <div id=3D"_x0000_s11266_561_634" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:66.25%; left:2.8%;width:107.67%;height:10.0%;white-space:nowrap'><span style=3D'position:absolute;top:0%;left:4.0%;width:96.0%;height:57.5%'><span style=3D'font-family:"Century Gothic";font-size:75%;font-weight:bold'><span style=3D'mso-special-format:"numbullet3\,1";position:absolute;left:-4.16%'= >6.</span></span><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>Zvýše= né riziko opakování v rodinách, kde jsou rodiče </b= ></span></span><span style=3D'position:absolute;top:42.5%;left:4.0%;width:83.82%;height:57.5%'>= <span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>pokrevně příbuznými </b></span></span></div> <div id=3D"_x0000_s11266_634_679" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:75.75%; left:2.8%;width:94.38%;height:5.75%;white-space:nowrap'><span style=3D'position:absolute;top:0%;left:4.56%;width:95.63%;height:100.0%'><= span style=3D'font-family:"Century Gothic";font-size:75%;font-weight:bold'><span style=3D'mso-special-format:"numbullet3\,1";position:absolute;left:-4.77%'= >7.</span></span><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>Výrazn&yac= ute; je podíl faktorů (zevního) prostředí </= b></span></span></div> <div id=3D"_x0000_s11266_679_852" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:81.25%; left:2.8%;width:105.61%;height:18.5%;white-space:nowrap'><span 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gSldJump && event.keyCode =3D=3D 13 ) { var numSlds =3D parent.GetSldList().mList.length if ( gSldJumpIdx > numSlds ) gSldJumpIdx =3D numSlds; if ( gSldJumpIdx >=3D 0 ) { if ( gSldJumpIdx =3D=3D 0 ) gSldJumpIdx =3D 1; var jumpTo =3D parseInt(gSldJumpIdx); gSldJump =3D 0; gSldJumpIdx =3D ""; win.GoToSld( parent.GetSldList().mList[jumpTo-1].mSldHref ) } } } function _KDH() { if( event.keyCode =3D=3D 8 ) { event.returnValue =3D 0; parent.GoToPrevSld(); } } function DocumentOnClick() { if( IsNts() || parent.HideMenu() ) return; if( ( g_allowAdvOnClick && (window.name=3D=3D"PPTSld") && !parent.IsFrames= Mode() ) || (event && event.keyCode=3D=3D32) ) { if( g_animUseRuntime && g_animMainSequence && g_animMainSequence.cangonex= t ) return; parent.GoToNextSld(); } } var g_supportsPPTHTML =3D SupportsPPTHTML(), g_scaleInFrame =3D 1, gId=3D""= , g_bgSound=3D"", g_scaleHyperlinks =3D false, g_allowAdvOnClick =3D 1, g_showInBrowser = =3D 0, gLoopCont =3D 0, gUseSldTimings =3D 1; var g_showAnimation =3D g_supportsPPTHTML && SupportsPPTAnimation() && ( (w= indow.name=3D=3D"PPTSld" && !parent.IsFramesMode()) || g_showInBrowser );va= r g_animManager =3D null; var g_animUseRuntime =3D false; var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime; var g_animMainSequence =3D null; var ENDSHOW_MESG=3D"Konec prezentace, klepnutím ukončíte= předvádění.", SCREEN_MODE=3D"Frames", gIsEndShow= =3D0, NUM_VIS_SLDS=3D10, SCRIPT_HREF=3D"script.js", FULLSCR_HREF=3D"fullscr= een.htm"; var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO= tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true window.gPPTHTML=3DSupportsPPTHTML() var gMainDoc=3Dnew Array(new hrefList("slide0001.htm",1,-1,1),new hrefList(= "slide0004.htm",1,-1,1),new hrefList("slide0005.htm",1,-1,1),new hrefList("= slide0007.htm",1,-1,1),new hrefList("slide0003.htm",1,-1,1),new hrefList("s= lide0015.htm",1,-1,1),new hrefList("slide0017.htm",1,-1,1),new hrefList("sl= ide0016.htm",1,-1,1),new hrefList("slide0019.htm",1,-1,1),new hrefList("sli= de0020.htm",1,-1,1)); function FullScrInit() { g_allowAdvOnClick =3D GetCurSld().mAdvOnClk document.body.style.backgroundColor=3D"black" document.oncontextmenu=3Dparent._CM; document.onkeydown =3D _KDH; document.ondragstart=3DCancel document.onselectstart=3DCancel self.focus() } function Redirect( frmId ) { var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId() if(idx>=3D0) str=3Dstr.substr(1); if( window.name !=3D frmId && ( sId !=3D str) ) { obj =3D GetObj("Main-File") window.location.href=3Dobj.href+"#"+sId return 1 } return 0 } var MHTMLPrefix =3D CalculateMHTMLPrefix(); function CalculateMHTMLPrefix() { if ( document.location.protocol =3D=3D 'mhtml:') { href=3Dnew String(document.location.href) Start=3Dhref.indexOf('!')+1 End=3Dhref.lastIndexOf('/')+1 if (End < Start) return href.substring(0, Start) else return href.substring(0, End) } return ''; } function GetTags(base,tag) { if(g_supportsPPTHTML) return base.all.tags(tag); else return base.getElementsByTagName(tag); } function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ClearMedia() { if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() { if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else return gCurSld } function GetNumSlds() { if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii<GetSldList().mList.length; ii++) { if ( GetSldList().mList[ii].mSldHref =3D=3D href ) return ii+1 } return 1 } function GetHrefObj( sldIdx ){ return GetSldList().mList[sldIdx-1] } function IsFramesMode(){ return ( SCREEN_MODE =3D=3D "Frames" ) } function IsFullScrMode(){ return ( SCREEN_MODE =3D=3D "FullScreen" ) } function GoToNextSld() { ii=3DgCurSld + 1 if( GetHrefObj( ii-1 ).mOrigVis =3D=3D 0 ) { if( ii<=3DGetSldList().mList.length ) { obj=3DGetHrefObj(ii) obj.mVis=3D1 GoToSldNum(ii) return } } else { obj=3DGetHrefObj( ii ) while ( obj && ( obj.mOrigVis =3D=3D 0 ) ) obj=3DGetHrefObj(++ii) if( obj && obj.mOrigVis ) { GoToSldNum(ii) return } } if( gSldStack.length > 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('<html><body dir=3D' + dir + ' bgcolor=3Dblack onload=3Dparent= .SetupEndShow() onunload=3Dparent.Unload()><center><p><font face=3DTahoma c= olor=3Dwhite size=3D2><br><b>' + ENDSHOW_MESG + '</b></font></p></center></= body></html>') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii<arr.length;ii++) { this.mList[ii] =3D new hrefList( arr[ii].mSldHref, arr[ii].mOrigVis, arr[= ii].mAdvDelay, arr[ii].mAdvOnClk ); if( arr[ii].mOrigVis ) this.mList[ii].mSldIdx =3D idx++; } this.mNumVisSlds =3D idx-1; this.fEndShow =3D fEnd; } function GetSldList() { return gSldStack[gSldStack.length-1] } function GetCurSld() { return parent.GetSldList().mList[parent.gCurSld - 1]= } gSldStack =3D new Array(); gSldStack[0] =3D new SldList(gMainDoc,gCurSld,1) function ToggleOtlPane() { frmset=3Ddocument.all("PPTHorizAdjust") frm=3Ddocument.all("PPTOtl") if( gOtlOpen ) frmset.cols=3D"*,100%" else frmset.cols=3D"25%,*" gOtlOpen=3D!gOtlOpen frm.noResize=3D!frm.noResize UpdOtNavPane() } function ToggleNtsPane() { frmset=3Ddocument.all("PPTVertAdjust") frm=3Ddocument.all("PPTNts") if( gNtsOpen ) frmset.rows=3D"100%,*" else frmset.rows=3D"*,20%" gNtsOpen=3D!gNtsOpen UpdNtsPane() } function ViewCustomShow(idx,fEnd) { if( !IsFullScrMode() ) return; var sldList =3D new Array(); var custShow =3D custShowList[idx-1]; var jj =3D 0; for( ii=3D0;ii<custShow.length;ii++ ) { if( custShow[ii] <=3D gMainDoc.length ) sldList[jj++] =3D gMainDoc[custShow[ii]-1]; } if (sldList.length > 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); function ImgBtn( oId,bId,w,action ) { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } function TxtBtn( oId,oeId,action,chkState ) { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() { b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() { b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState var sNext=3D"Další",sPrev=3D"Předchozí",sEnd=3D"Kon= ec prezentace",sFont=3D"Arial",sArrow=3D"Šipka",sFreeform=3D"Voln&yacu= te; tvar",sRect=3D"Obdélník",sOval=3D"Ovál" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); 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snímek" style=3D'position:relative; left:-90px'></div> </div> </td> </table> </div> <div id=3DOtlNavObj onload=3D"Load()" onmouseover=3D"BtnOnOver()" onmousedown=3D"BtnOnDown()" onmouseout=3D"BtnOnOut()" onmouseup=3D"BtnOnUp(= )" onkeypress=3D"ExecBtn()" style=3D'display:none;visibility:hidden'> <table style=3D'position:relative;width:70px' align=3Dleft cellpadding=3D0 = cellspacing=3D0> <td nowrap><div title=3D"Zobrazit či skrýt osnovu" id=3D"nb_otl" onfocus=3D"BtnOnOver()" onblur= =3D"BtnOnOut()" TABINDEX=3D11 style=3D'position:absolute;top:0%;left:0%;width:100%;height:100%;cursor:de= fault'> <div id=3D"nb_otlElem" align=3Dcenter style=3D'position:relative;padding:3= px;font-family:Arial; color:buttontext;font-size:9pt'>Osnova</div></div> </td> </table> <table style=3D'position:relative' align=3Dcenter cellpadding=3D0 cellspaci= ng=3D0> <td> <div style=3D'position:absolute;left:-18px;width:24px;height:20px;border-s= tyle: solid;border-width:1px;border-color:threedface' onfocus=3D"BtnOnOver()" on= blur=3D"BtnOnOut()" TABINDEX=3D12 id=3D"nb_otlTxtBorder"> <div style=3D'position:absolute;clip:rect(0px, 22px, 18px, 0px)'><img src=3Dbuttons.gif id=3D"nb_otlTxt" title=3D"Sbalit či rozbalit osnovu" style=3D'position:relative;left:-157px'></div> </div> </td> </table> </div> <div id=3DOtlObj style=3D'display:none;visibility:hidden;'> <table width=3D"100%" style=3D'font-family:Arial;font-size:9pt'> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>1</font></div> </td> <td width=3D"100%"> <div id=3DPPTP1 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0001.htm');" id=3DPPTL1><br> INTERAKCE NEALELNÍCH GENŮ<br> <span style=3D'mso-spacerun:yes'> </span>POLYGENNÍ DĚDIČNOST</a></font></div> <div id=3DPPTC1 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <br> <li>© Aleš Panczak, ÚBLG 1. LF a VFN</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>2</font></div> </td> <td> <div id=3DPPTP2 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0004.htm');" id=3DPPTL2>Krátk&eac= ute; opakování:</a></font></div> <div id=3DPPTC2 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Jednotková dědičnost</li> <ul> <li>podíl alel téhož genu (lokusu) při utváření fenotypu hybrida</li> <li>rozdíly ve stupni dominance alel</li> </ul> <li>Alelní a nealelní geny</li> <li>Dihybridismus</li> <ul> <li>16tipolní tabulka genotypových kombinací</li> <li>genotypové a fenotypové štěpné poměry.</li> </ul> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>3</font></div> </td> <td> <div id=3DPPTP3 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0005.htm');" id=3DPPTL3>Úvod I:</= a></font></div> <div id=3DPPTC3 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>na genetické determinaci určitých znaků se spolupodílejí alely dvou, tří a více genů</li> <ul> <li>gény modifikátory, modifikátorové gény - určité gény jen pozměňují (modifikují) stupeň projevu jiných nealelních genů</li> <li>genová interakce - pokud alely určitých genů zcela zásadně mění fenotypový účinek alel jiných genů, znak vzniká spolupůsobením dvou nebo více nealelních genů</li> </ul> <li>geny komplementární, epistatické nebo suplementární - podle toho, jak rovnoměrně se jednotlivé geny na výsledném fenotypu uplatňují, přehled v tabulkách na str. 47 a = 48Kot.</li> <li>význam modelových příkladů z rostlinné a zejména savčí genetiky – u člověka je analýza situace komplikovanější.</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>4</font></div> </td> <td> <div id=3DPPTP4 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0007.htm');" id=3DPPTL4>Bombayský= fenotyp v systému ABO<br> <span style=3D'mso-spacerun:yes'> </span>př. 6/s= tr. 50 Kot</a></font></div> <div id=3DPPTC4 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Závěr: suplementarita, recesivní epistáze, příklad metabolického řetězce.</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>5</font></div> </td> <td> <div id=3DPPTP5 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0003.htm');" id=3DPPTL5><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>6</font></div> </td> <td> <div id=3DPPTP6 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0015.htm');" id=3DPPTL6>Úvod II:<= br> Rekapitulace základních pojmů</a></font></div> <div id=3DPPTC6 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>multifaktoriální znaky</li> <li>polygenní dědičnost</li> <li>major a minor gény</li> <li>gény-modifikátory</li> <li>aktivní a neaktivní alely</li> <li>aditivní účinek alel</li> <li>variabilita podmíněná genotypem a<span style=3D'mso-spacerun:yes'> </span>prostředím</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>7</font></div> </td> <td> <div id=3DPPTP7 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0017.htm');" id=3DPPTL7>Odvození štěpných poměrů<br> Pascalův trojúhelník</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>8</font></div> </td> <td> <div id=3DPPTP8 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0016.htm');" id=3DPPTL8>Odvození štěpných poměrů pro n alel<br> př. 9/str. 50 Kot</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>9</font></div> </td> <td> <div id=3DPPTP9 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0019.htm');" id=3DPPTL9>Orientačn&i= acute; stanovení rizika u polygenní dědičnosti</a></font= ></div> <div id=3DPPTC9 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>O multifaktoriální etiologii lze uvažovat, kdy= 82; má choroba zjevně familiální výskyt, avšak nelze jednoznačně určit typ dědičnosti v rodině</li> <li>Riziko pro příbuzné I. stupně je přibližně odmocninou z rizika populačního (incidence) – Edwardsův vzorec</li> <li>Riziko je podstatně nižší pro příbuzné II. stupně, pro vzdálenější příbuzné klesá již méně rychle</li> <li>Riziko je vyšší, když je postiženo více členů rodiny – pro příbuzné I. stupně se hodnota vypočtená podle Edwardsova vzorce násobí 2= , 3 apod.</li> <li>Čím těžší je postižení či dřívější manifestace tím vyšší je riziko opakování</li> <li>Zvýšené riziko opakování v rodinách, kde jsou rodiče pokrevně příbuznými</li> <li>Výrazný je podíl faktorů (zevního) prostředí</li> <li>Pokud je sledovaný znak častější u jedn= oho pohlaví než u druhého, pak je riziko opakování vyšší pro příbuzné pacienta, který je pří= ;slušníkem méně často postiženého pohlaví.<= /li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>10</font></div> </td> <td> <div id=3DPPTP10 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0020.htm');" id=3DPPTL10>Riziko rozštěpu neurální trubice<br> Úkol č. 15/str 52 Kot</a></font></div> <div id=3DPPTC10 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>VVV s multifaktoriální etiologií a polygenn&iac= ute; 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xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 12"> <link id=3DMain-File rel=3DMain-File href=3D"../interakcepolygenprakt.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>genové interakce a polygenní dědičnost</titl= e> <![if IE]> <base href=3D"file:///C:\D13A91D4\interakcepolygenprakt_soubory\slide0004.h= tm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"4.12.2009: Krátké opakov&= aacute;ní:"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><o:shapelayout 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style=3D'position:absolute;top:44.5%;left:14.04%;width:79.96%;height:6.0%'= ><b>fenotypu hybrida </b></span></div> <div class=3DB1 style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:a= bsolute; top:52.0%;left:11.04%;width:83.14%;height:6.0%'><span style=3D'position:ab= solute; top:0%;left:3.6%;width:96.17%;height:100.0%'><span style=3D'mso-special-fo= rmat: bullet;position:absolute;left:-3.74%'>–</span><b>rozdíly ve stupni dominance alel </b></span></div> <div class=3DB style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:59.75%;left:5.99%;width:88.2%;height:6.75%'><span style=3D'position:ab= solute; top:0%;left:4.24%;width:95.75%;height:100.0%'><span style=3D'mso-special-f= ormat: bullet;position:absolute;left:-4.43%'>•</span><b>Alelní a nealelní geny </b></span></div> <div class=3DB style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:ab= solute; top:68.25%;left:5.99%;width:88.2%;height:6.75%'><span style=3D'position:ab= solute; top:0%;left:4.24%;width:95.75%;height:100.0%'><span style=3D'mso-special-f= ormat: bullet;position:absolute;left:-4.43%'>•</span><b>Dihybridismus <= /b></span></div> <div class=3DB1 style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:a= bsolute; top:76.5%;left:11.04%;width:97.56%;height:6.0%'><span style=3D'position:ab= solute; top:0%;left:3.07%;width:96.92%;height:100.0%'><span style=3D'mso-special-f= ormat: bullet;position:absolute;left:-3.16%'>–</span><b>16tipolní tabulka genotypových kombinací </b></span></div> <div class=3DB1 style=3D'mso-char-wrap:1;mso-kinsoku-overflow:1;position:a= bsolute; top:84.0%;left:11.04%;width:95.5%;height:6.0%'><span style=3D'position:abs= olute; top:0%;left:3.13%;width:96.86%;height:100.0%'><span style=3D'mso-special-f= ormat: bullet;position:absolute;left:-3.23%'>–</span><b>genotypové a fenotypové štěpné poměry. </b></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01CA753A.A0BCA130 Content-Location: file:///C:/D13A91D4/interakcepolygenprakt_soubory/slide0005.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 12"> <link id=3DMain-File rel=3DMain-File href=3D"../interakcepolygenprakt.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>genové interakce a polygenní dědičnost</titl= e> <![if IE]> <base href=3D"file:///C:\D13A91D4\interakcepolygenprakt_soubory\slide0005.h= tm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"4.12.2009: Úvod I:"> <link rel=3DStylesheet href=3D"master03_stylesheet.css"> <![if !ppt]> <style media=3Dprint>  </style> <script src=3Dscript.js></script><script></script><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"5"/> </o:shapelayout> </head> <body lang=3DCS style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; width:534px;height:400px;font-size:16px;background-color:#CCFFCC;clip:rect(= 0%, 101%, 101%, 0%); visibility:hidden'><p:slide coordsize=3D"720,540" colors=3D"#ffffff,#000000,#808080,#000000,#bbe0e3,#333399,#009999,#99cc00" masterhref=3D"master03.xml"> <v:background id=3D"_x0000_s5121" o:bwmode=3D"white" fillcolor=3D"#cfc"> <v:fill color2=3D"#339 [5]"/> </v:background><![if !ppt]><p:shaperange href=3D"master03.xml#_x0000_s1028= "/><p:shaperange href=3D"master03.xml#_x0000_s1029"/><![endif]><p:shaperange href=3D"master03.xml#_x0000_m1026"/><v:shape id=3D"_x0000_s5122" type=3D"= #_x0000_m1026" style=3D'position:absolute;left:36pt;top:14.875pt;width:9in;height:44.25p= t; visibility:visible;mso-wrap-style:square;v-text-anchor:middle'> <v:stroke o:forcedash=3D"f"/> <v:path arrowok=3D"f"/> <o:lock v:ext=3D"edit" rotation=3D"f" aspectratio=3D"f" position=3D"f" se= lection=3D"f" verticies=3D"f" text=3D"f" adjusthandles=3D"f" grouping=3D"t" shapetype= =3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate-with-shape:t' inset= =3D"7.2pt,3.6pt,7.2pt,3.6pt"/> <p:placeholder type=3D"title" position=3D"-1"/></v:shape><p:shaperange href=3D"master03.xml#_x0000_m1027"/><v:shape id=3D"_x0000_s5123" type=3D"= #_x0000_m1027" style=3D'position:absolute;left:19.75pt;top:60.25pt;width:686.125pt;heigh= t:464.875pt; visibility:visible;mso-wrap-style:square;v-text-anchor:top'> <v:stroke o:forcedash=3D"f"/> <v:path arrowok=3D"f"/> <o:lock v:ext=3D"edit" rotation=3D"f" aspectratio=3D"f" position=3D"f" se= lection=3D"f" verticies=3D"f" text=3D"f" adjusthandles=3D"f" grouping=3D"t" shapetype= =3D"f"/> <v:textbox style=3D'layout-flow:horizontal;mso-rotate-with-shape:t' inset= =3D"7.2pt,3.6pt,7.2pt,3.6pt"/> <p:placeholder type=3D"body" position=3D"-1"/></v:shape> <div v:shape=3D"_x0000_s5122" class=3DT style=3D'mso-char-wrap:1;mso-kinso= ku-overflow: 1;position:absolute;top:3.0%;left:5.99%;width:88.2%;height:8.5%'><span style=3D'font-size:91%'><b>Úvod I:</b></span></div> <div v:shape=3D"_x0000_s5123"> <div class=3DB style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-kin= soku-overflow: 1'><span style=3D'position:absolute;top:11.25%;left:7.49%;width:93.63%; height:6.0%'><span style=3D'font-size:88%'><span style=3D'mso-special-form= at:bullet; position:absolute;left:-4.0%'>•</span></span><span style=3D'font-siz= e: 88%'><b>na genetické determinaci</b></span><span style=3D'font-size= :88%'> určitých znaků </span><span style=3D'font-size:88%'><b>se= </b></span></span><span style=3D'position:absolute;top:16.25%;left:7.49%;width:89.7%;height:6.0%'>= <span style=3D'font-size:88%'><b>spolupodílejí</b></span><span style=3D'font-size:88%'> alely dvou, tří a více genů </span></span></div> <div class=3DB1 style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-ki= nsoku-overflow: 1'><span style=3D'position:absolute;top:22.25%;left:11.79%;width:91.57%; height:6.0%'><span style=3D'mso-special-format:bullet;position:absolute; left:-3.27%'>–</span><b>gény modifikátory</b>, <b>modi= fikátorové gény</b> - </span><span style=3D'position:absolute;top:27.25%;left:= 11.79%; width:93.07%;height:6.0%'>určité gény jen pozměňují (modifikují) stupeň </span><span style=3D'position:absolute;top:32.25%;left:11.79%;width:85.39%;height:6.0%= '>projevu jiných nealelních genů </span></div> <div class=3DB1 style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-ki= nsoku-overflow: 1'><span style=3D'position:absolute;top:38.5%;left:11.79%;width:95.31%; height:6.0%'><span style=3D'mso-special-format:bullet;position:absolute; left:-3.14%'>–</span><b>genová interakce </b>- pokud alely určitých genů </span><span style=3D'position:absolute; top:43.5%;left:11.79%;width:102.24%;height:6.0%'>zcela zásadně mění fenotypový účinek alel jiných <= /span><span style=3D'position:absolute;top:48.5%;left:11.79%;width:96.44%;height:6.0%'= >genů, znak vzniká spolupůsobením dvou nebo </span><span style=3D'position:absolute;top:53.5%;left:11.79%;width:85.39%;height:6.0%'= >více nealelních genů </span></div> <div class=3DB style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-kin= soku-overflow: 1'><span style=3D'position:absolute;top:59.75%;left:7.49%;width:89.7%; height:6.0%'><span style=3D'font-size:88%'><span style=3D'mso-special-form= at:bullet; position:absolute;left:-4.17%'>•</span></span><span style=3D'font-si= ze: 88%'><b>geny komplementární, epistatické nebo </b></s= pan></span><span style=3D'position:absolute;top:64.75%;left:7.49%;width:99.25%;height:6.0%'= ><span style=3D'font-size:88%'><b>suplementární</b></span><span style=3D'font-size:88%'> - podle toho, jak rovnoměrně se </span>= </span><span style=3D'position:absolute;top:69.75%;left:7.49%;width:101.12%;height:6.0%= '><span style=3D'font-size:88%'>jednotlivé geny na výsledném fenotypu uplatňují, </span></span><span style=3D'position:abso= lute; top:74.75%;left:7.49%;width:89.7%;height:6.0%'><span style=3D'font-size:88= %'>přehled v tabulkách na str. 47 a 48</span><span style=3D'font-size:88%'><i>= Kot</i></span><span style=3D'font-size:88%'>. </span></span></div> <div class=3DB style=3D'mso-line-spacing:"80 20 0";mso-char-wrap:1;mso-kin= soku-overflow: 1'><span style=3D'position:absolute;top:80.75%;left:7.49%;width:91.94%; height:6.0%'><span style=3D'font-size:88%'><span style=3D'mso-special-form= at:bullet; position:absolute;left:-4.07%'>•</span></span><span style=3D'font-si= ze: 88%'><b>význam modelových příkladů</b></spa= n><span style=3D'font-size:88%'> z rostlinné a </span></span><span style=3D'position:absolute;top:85.75%;left:7.49%;width:96.06%;height:6.0%'= ><span style=3D'font-size:88%'>zejména savčí genetiky – u člověka je analýza </span></span><span style=3D'position:= absolute; top:90.75%;left:7.49%;width:89.7%;height:6.0%'><span style=3D'font-size:88= %'>situace komplikovanější.</span></span></div> </div> </p:slide></div> </body> </html> ------=_NextPart_01CA753A.A0BCA130 Content-Location: file:///C:/D13A91D4/interakcepolygenprakt_soubory/slide0007.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" <html xmlns:v=3D"urn:schemas-microsoft-com:vml" xmlns:o=3D"urn:schemas-microsoft-com:office:office" xmlns:p=3D"urn:schemas-microsoft-com:office:powerpoint" xmlns:oa=3D"urn:schemas-microsoft-com:office:activation" xmlns=3D"http://www.w3.org/TR/REC-html40"> <head> <meta http-equiv=3DContent-Type content=3D"text/html; charset=3Dus-ascii"> <meta name=3DProgId content=3DPowerPoint.Slide> <meta name=3DGenerator content=3D"Microsoft PowerPoint 12"> <link id=3DMain-File rel=3DMain-File href=3D"../interakcepolygenprakt.htm"> <link rel=3DPreview href=3Dpreview.wmf>  <title>genové interakce a polygenní dědičnost</titl= e> <![if IE]> <base href=3D"file:///C:\D13A91D4\interakcepolygenprakt_soubory\slide0007.h= tm" id=3D"webarch_temp_base_tag"> <![endif]> <meta name=3DDescription content=3D"4.12.2009: Bombayský fenotyp v systému ABO p&#= 345;. 6/str. 50 Kot"> <link rel=3DStylesheet href=3D"master03_stylesheet.css">  <![if !ppt]> <style media=3Dprint>  </style> <style>  </style> <script src=3Dscript.js></script><script></script><script></script><![endif]><o:shapelayout v:ext=3D"edit"> <o:idmap v:ext=3D"edit" data=3D"6"/> </o:shapelayout> </head> <body lang=3DCS style=3D'margin:0px;background-color:black' onclick=3D"DocumentOnClick()" onresize=3D"_RSW()" onload=3D"LoadSld()" onkeypress=3D"_KPH()" oa:clockstart=3D"onstart"> <div id=3DSlideObj class=3Dsld style=3D'position:absolute;top:0px;left:0px; 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style=3D'mso-margin-left-alt:1008'></div> <div class=3DO4 style=3D'mso-margin-left-alt:1296'></div> <div class=3DO><span style=3D'position:absolute;top:23.75%;left:3.55%;widt= h:52.99%; height:5.75%'><span style=3D'font-family:Verdana;mso-ascii-font-family:Ver= dana; mso-hansi-font-family:Verdana;font-size:133%'>Homozygocie alel jednoho </s= pan></span><span style=3D'position:absolute;top:29.25%;left:3.55%;width:46.06%;height:5.75%= '><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>genu postihuje expresi </span></span><span style=3D'position:absolute;top:34.5%;left:3.55%;width:45.69%;height:5.75%'= ><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>genu druhého</span><span lang=3DEN-US style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>.</span></span></div> </div> <div v:shape=3D"_x0000_s7173"> <div class=3DO1 style=3D'mso-margin-left-alt:468'></div> <div class=3DO2 style=3D'mso-margin-left-alt:720'></div> <div class=3DO3 style=3D'mso-margin-left-alt:1008'></div> <div class=3DO4 style=3D'mso-margin-left-alt:1296'></div> <div class=3DO style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:225; mso-char-wrap:1;mso-kinsoku-overflow:1'><span style=3D'position:absolute; top:44.0%;left:7.67%;width:40.82%;height:5.75%'><span style=3D'font-family= :Verdana; font-size:133%'><span style=3D'mso-special-format:bullet;position:absolute; left:-9.63%'>•</span></span><span style=3D'font-family:Verdana;mso-a= scii-font-family: Verdana;mso-hansi-font-family:Verdana;font-size:133%'>Gen </span><span lang=3DEN-US style=3D'font-family:Verdana;mso-ascii-font-family:Verdana; mso-hansi-font-family:Verdana;font-size:133%'>H </span><span style=3D'font= -family: Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-family:Verdana; font-size:133%'>je</span><span lang=3DEN-US style=3D'font-family:Verdana; mso-ascii-font-family:Verdana;mso-hansi-font-family:Verdana;font-size:133%= '> epistatic</span><span style=3D'font-family:Verdana;mso-ascii-font-family:V= erdana; mso-hansi-font-family:Verdana;font-size:133%'>ký </span></span><span style=3D'position:absolute;top:48.75%;left:7.67%;width:40.26%;height:5.75%= '><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>genu</span><span lang=3DEN-US style=3D'font-family= :Verdana; mso-ascii-font-family:Verdana;mso-hansi-font-family:Verdana;font-size:133%= '> AB</span><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana; mso-hansi-font-family:Verdana;font-size:133%'>0</span><span lang=3DEN-US style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>.</span><span lang=3DEN-US style=3D'font-family:Ve= rdana; mso-ascii-font-family:Verdana;mso-hansi-font-family:Verdana;font-size:133%; display:none'><b> </b></span></span></div> <div class=3DO style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:225; mso-char-wrap:1;mso-kinsoku-overflow:1'><span style=3D'position:absolute; top:54.5%;left:7.67%;width:43.82%;height:5.75%'><span style=3D'font-family= :Verdana; font-size:133%'><span style=3D'mso-special-format:bullet;position:absolute; left:-8.97%'>•</span></span><span style=3D'font-family:Verdana;mso-a= scii-font-family: Verdana;mso-hansi-font-family:Verdana;font-size:133%'>Genotyp </span><span lang=3DEN-US style=3D'font-family:Verdana;mso-ascii-font-family:Verdana; mso-hansi-font-family:Verdana;font-size:133%'><i>hh</i></span><span lang=3DEN-US style=3D'font-family:Verdana;mso-ascii-font-family:Verdana; mso-hansi-font-family:Verdana;font-size:133%'> =3D </span><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>netvoří </span></span><span style=3D'position:absolute;top:59.5%;left:7.67%;width:40.26%;height:5.75%'= ><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>se substance </span><span lang=3DEN-US style=3D'fo= nt-family: Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-family:Verdana; font-size:133%'>H.</span><span style=3D'font-family:Verdana;mso-ascii-font= -family: Verdana;mso-hansi-font-family:Verdana;font-size:133%;display:none'> </= span></span></div> <div class=3DO style=3D'mso-line-spacing:"90 20 0";mso-margin-left-alt:225; mso-char-wrap:1;mso-kinsoku-overflow:1'><span style=3D'position:absolute; top:65.25%;left:7.67%;width:46.44%;height:5.75%'><span style=3D'font-famil= y: Verdana;font-size:133%'><span style=3D'mso-special-format:bullet;position:= absolute; left:-8.46%'>•</span></span><span style=3D'font-family:Verdana;mso-a= scii-font-family: Verdana;mso-hansi-font-family:Verdana;font-size:133%'>Všechny genotypy AB0 </span></span><span style=3D'position:absolute;top:70.0%;left:7.67%; width:44.38%;height:5.75%'><span style=3D'font-family:Verdana;mso-ascii-fo= nt-family: Verdana;mso-hansi-font-family:Verdana;font-size:133%'>se budou „tvářit“ jako </span></span><span style=3D'positio= n: absolute;top:74.75%;left:7.67%;width:40.26%;height:5.75%'><span style=3D'font-family:Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-= family: Verdana;font-size:133%'>skupina 0.</span><span lang=3DEN-US style=3D'font-= family: Verdana;mso-ascii-font-family:Verdana;mso-hansi-font-family:Verdana; font-size:133%;mso-special-format:lastCR;display:none'> </span></span>= </div> </div> </p:slide></div> </body> </html> ------=_NextPart_01CA753A.A0BCA130 Content-Location: file:///C:/D13A91D4/interakcepolygenprakt_soubory/slide0003_image007.jpg Content-Transfer-Encoding: base64 Content-Type: image/jpeg /9j/4AAQSkZJRgABAQEAYABgAAD/2wBDAAgGBgcGBQgHBwcJCQgKDBQNDAsLDBkSEw8UHRofHh0a HBwgJC4nICIsIxwcKDcpLDAxNDQ0Hyc5PTgyPC4zNDL/2wBDAQkJCQwLDBgNDRgyIRwhMjIyMjIy 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style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>O multifaktoriální etiologii lze uvažovat, když má </b></span></span><span style=3D'position:absolute;top:29.82%; left:4.39%;width:92.16%;height:40.35%'><span style=3D'font-family:"Century= Gothic"; mso-ascii-font-family:"Century Gothic";mso-hansi-font-family:"Century Goth= ic"; font-size:75%'><b>choroba zjevně familiální výsk= yt, avšak nelze </b></span></span><span style=3D'position:absolute;top:59= .64%; left:4.39%;width:92.16%;height:40.35%'><span style=3D'font-family:"Century= Gothic"; mso-ascii-font-family:"Century Gothic";mso-hansi-font-family:"Century Goth= ic"; font-size:75%'><b>jednoznačně určit typ dědičnost= i v rodině </b></span></span></div> <div id=3D"_x0000_s11266_139_245" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:23.75%; left:2.8%;width:109.17%;height:10.0%;white-space:nowrap'><span style=3D'position:absolute;top:0%;left:3.94%;width:96.22%;height:57.5%'><s= pan style=3D'font-family:"Century Gothic";font-size:75%;font-weight:bold'><span style=3D'mso-special-format:"numbullet3\,1";position:absolute;left:-4.09%'= >2.</span></span><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>Riziko pro příbuzné I. stupně je přibližně odmocninou z </b></span></span><span style=3D'position:absolute;top:42.5%; left:3.94%;width:90.73%;height:57.5%'><span style=3D'font-family:"Century = Gothic"; mso-ascii-font-family:"Century Gothic";mso-hansi-font-family:"Century Goth= ic"; font-size:75%'><b>rizika populačního (incidence) – Edwardsův vzorec </b></span></span></div> <div id=3D"_x0000_s11266_245_343" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:33.25%; 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c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>Edwardsova vzorce násobí 2, 3 apod. </b></span></span></div> <div id=3D"_x0000_s11266_484_561" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:56.75%; left:2.8%;width:110.86%;height:10.0%;white-space:nowrap'><span style=3D'position:absolute;top:0%;left:3.88%;width:96.11%;height:57.5%'><s= pan style=3D'font-family:"Century Gothic";font-size:75%;font-weight:bold'><span style=3D'mso-special-format:"numbullet3\,1";position:absolute;left:-4.04%'= >5.</span></span><span style=3D'mso-ascii-font-family:"Century Gothic";mso-hansi-font-family:"Cen= tury Gothic"; font-size:75%'><b>Čím těžší je postižení či dřívější manifestace tím vyšší je </b></span></span><span style=3D'position:absolute;top:42.5%;left:3.88%;width:81.41%;height:57.5%'= ><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>riziko opakování </b></span></span></div> <div id=3D"_x0000_s11266_561_634" style=3D'mso-line-spacing:"80 20 0";mso-= margin-left-alt: 240;mso-char-wrap:1;mso-kinsoku-overflow:1;position:absolute;top:66.25%; left:2.8%;width:107.67%;height:10.0%;white-space:nowrap'><span style=3D'position:absolute;top:0%;left:4.0%;width:96.0%;height:57.5%'><span style=3D'font-family:"Century Gothic";font-size:75%;font-weight:bold'><span style=3D'mso-special-format:"numbullet3\,1";position:absolute;left:-4.16%'= >6.</span></span><span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>Zvýše= né riziko opakování v rodinách, kde jsou rodiče </b= ></span></span><span style=3D'position:absolute;top:42.5%;left:4.0%;width:83.82%;height:57.5%'>= <span style=3D'font-family:"Century Gothic";mso-ascii-font-family:"Century Gothi= c"; mso-hansi-font-family:"Century Gothic";font-size:75%'><b>pokrevně 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g_scaleHyperlinks=3D(document.all.tags("AREA").length>0) if( g_scaleHyperlinks ) InitHLinkArray() if( g_scaleInFrame||(IsWin("PPTSld") && parent.IsFullScrMode() ) ) document.body.scroll=3D"no" _RSW() if( IsWin("PPTSld") && parent.IsFullScrMode() ) FullScrInit(); =09 MakeSldVis(); ChkAutoAdv() if( runAnimations ) { if( document.all("NSPlay") ) document.all("NSPlay").autoStart =3D false; if( sld.filters && sld.filters.revealtrans ) setTimeout( "document.body.start()", sld.filters.revealtrans.duration * = 1000 ); else document.body.start(); } } function MakeSldVis() { var fTrans=3Dg_showAnimation && SldHasTrans() if( fTrans ) { if( g_bgSound ) { idx=3Dg_bgSound.indexOf(","); pptSound.src=3Dg_bgSound.substr( 0, idx ); pptSound.loop=3D -(parseInt(g_bgSound.substr(idx+1))); } SlideObj.filters.revealtrans.Apply() } SlideObj.style.visibility=3D"visible" if( fTrans ) SlideObj.filters.revealtrans.Play() } function MakeNotesVis() { if( !IsNts() ) return false SlideObj.style.display=3D"none" nObj 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gSldJump && event.keyCode =3D=3D 13 ) { var numSlds =3D parent.GetSldList().mList.length if ( gSldJumpIdx > numSlds ) gSldJumpIdx =3D numSlds; if ( gSldJumpIdx >=3D 0 ) { if ( gSldJumpIdx =3D=3D 0 ) gSldJumpIdx =3D 1; var jumpTo =3D parseInt(gSldJumpIdx); gSldJump =3D 0; gSldJumpIdx =3D ""; win.GoToSld( parent.GetSldList().mList[jumpTo-1].mSldHref ) } } } function _KDH() { if( event.keyCode =3D=3D 8 ) { event.returnValue =3D 0; parent.GoToPrevSld(); } } function DocumentOnClick() { if( IsNts() || parent.HideMenu() ) return; if( ( g_allowAdvOnClick && (window.name=3D=3D"PPTSld") && !parent.IsFrames= Mode() ) || (event && event.keyCode=3D=3D32) ) { if( g_animUseRuntime && g_animMainSequence && g_animMainSequence.cangonex= t ) return; parent.GoToNextSld(); } } var g_supportsPPTHTML =3D SupportsPPTHTML(), g_scaleInFrame =3D 1, gId=3D""= , g_bgSound=3D"", g_scaleHyperlinks =3D false, g_allowAdvOnClick =3D 1, g_showInBrowser = =3D 0, gLoopCont =3D 0, gUseSldTimings =3D 1; var g_showAnimation =3D g_supportsPPTHTML && SupportsPPTAnimation() && ( (w= indow.name=3D=3D"PPTSld" && !parent.IsFramesMode()) || g_showInBrowser );va= r g_animManager =3D null; var g_animUseRuntime =3D false; var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime; var g_animMainSequence =3D null; var ENDSHOW_MESG=3D"Konec prezentace, klepnutím ukončíte= předvádění.", SCREEN_MODE=3D"Frames", gIsEndShow= =3D0, NUM_VIS_SLDS=3D10, SCRIPT_HREF=3D"script.js", FULLSCR_HREF=3D"fullscr= een.htm"; var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO= tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true window.gPPTHTML=3DSupportsPPTHTML() var gMainDoc=3Dnew Array(new hrefList("slide0001.htm",1,-1,1),new hrefList(= "slide0004.htm",1,-1,1),new hrefList("slide0005.htm",1,-1,1),new hrefList("= slide0007.htm",1,-1,1),new hrefList("slide0003.htm",1,-1,1),new hrefList("s= lide0015.htm",1,-1,1),new hrefList("slide0017.htm",1,-1,1),new hrefList("sl= ide0016.htm",1,-1,1),new hrefList("slide0019.htm",1,-1,1),new hrefList("sli= de0020.htm",1,-1,1)); function FullScrInit() { g_allowAdvOnClick =3D GetCurSld().mAdvOnClk document.body.style.backgroundColor=3D"black" document.oncontextmenu=3Dparent._CM; document.onkeydown =3D _KDH; document.ondragstart=3DCancel document.onselectstart=3DCancel self.focus() } function Redirect( frmId ) { var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId() if(idx>=3D0) str=3Dstr.substr(1); if( window.name !=3D frmId && ( sId !=3D str) ) { obj =3D GetObj("Main-File") window.location.href=3Dobj.href+"#"+sId return 1 } return 0 } var MHTMLPrefix =3D CalculateMHTMLPrefix(); function CalculateMHTMLPrefix() { if ( document.location.protocol =3D=3D 'mhtml:') { href=3Dnew String(document.location.href) Start=3Dhref.indexOf('!')+1 End=3Dhref.lastIndexOf('/')+1 if (End < Start) return href.substring(0, Start) else return href.substring(0, End) } return ''; } function GetTags(base,tag) { if(g_supportsPPTHTML) return base.all.tags(tag); else return base.getElementsByTagName(tag); } function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP= refix+GetHrefObj( gCurSld ).mNtsHref ) } function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() } function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() } function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() } function SetHasNts( fVal ) { if( gHasNts !=3D fVal ) { gHasNts=3DfVal UpdNavPane() } } function ToggleOtlText() { gOtlTxtExp=3D!gOtlTxtExp UpdOtlPane() } function ClearMedia() { if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0; } function FullScreen() { if ( PPTSld.g_animUseRuntime ) PPTSld.document.body.pause(); ClearMedia(); var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF = : FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref; if(PPTNav.event.ctrlKey) { var w =3D (window.screen.availWidth * 1.0) / 2.0 var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top= =3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } else { win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" ); if( win.document.body && PPTSld.g_animUseRuntime ) win.document.body.PPTSldFrameset=3Dwindow; } } function ToggleVNarration() { rObj=3DPPTSld.document.all("NSPlay") if( rObj && !PPTSld.g_animUseRuntime ) { if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) ) rObj.Play() else if( rObj.playState =3D=3D 2 ) rObj.Pause() else return; } else if( PPTSld.g_animUseRuntime ) { narObj =3D PPTSld.document.all("narrationID") if( narObj ) narObj.togglePause() } } function GetCurSldNum() { obj=3DGetHrefObj(gCurSld) if( obj.mOrigVis =3D=3D 1 ) return obj.mSldIdx else return gCurSld } function GetNumSlds() { if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 ) return GetSldList().mNumVisSlds; else return GetSldList().mList.length } function GetSldNum( href ) { for(ii=3D0; ii<GetSldList().mList.length; ii++) { if ( GetSldList().mList[ii].mSldHref =3D=3D href ) return ii+1 } return 1 } function GetHrefObj( sldIdx ){ return GetSldList().mList[sldIdx-1] } function IsFramesMode(){ return ( SCREEN_MODE =3D=3D "Frames" ) } function IsFullScrMode(){ return ( SCREEN_MODE =3D=3D "FullScreen" ) } function GoToNextSld() { ii=3DgCurSld + 1 if( GetHrefObj( ii-1 ).mOrigVis =3D=3D 0 ) { if( ii<=3DGetSldList().mList.length ) { obj=3DGetHrefObj(ii) obj.mVis=3D1 GoToSldNum(ii) return } } else { obj=3DGetHrefObj( ii ) while ( obj && ( obj.mOrigVis =3D=3D 0 ) ) obj=3DGetHrefObj(++ii) if( obj && obj.mOrigVis ) { GoToSldNum(ii) return } } if( gSldStack.length > 1 ) PopSldList(); else if( !IsFramesMode() ) { if( gLoopCont ) GoToFirst() else EndShow() } } function GoToPrevSld() { ii=3DgCurSld-1 if( ii > 0 ) { obj=3DGetHrefObj(ii) while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) ) obj=3DGetHrefObj(--ii) if( ii =3D=3D 0 ) ii=3D1 GoToSldNum(ii) } } function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) } function GoToLast() { ii=3DGetSldList().mList.length if( ii !=3D gCurSld ) GoToSld( GetHrefObj(ii).mSldHref ) } function GoToSldNum( num ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue obj =3D GetHrefObj( num ) obj.mVis=3D1 gPrevSld=3DgCurSld gCurSld =3D num; PPTSld.location.replace(MHTMLPrefix+obj.mSldHref) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function GoToSld( href ) { if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue GetHrefObj( GetSldNum(href) ).mVis=3D1 PPTSld.location.replace(MHTMLPrefix+href) } function SldUpdated( id ) { if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return gPrevSld=3DgCurSld gCurSld=3DGetSldNum(id) if( IsFramesMode() ) { UpdNavPane(); UpdOtlPane(); UpdNtsPane() } } function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) } function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO= bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) } function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) } function CloseWindow() { if( HideMenu() ) return; var event =3D PPTSld.event; if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D= =3D32 || event.type=3D=3D"click" ) ) window.close( self ); CatchNumKeys( self, event ); } function Unload() { gIsEndShow=3D0; } function SetupEndShow() { gIsEndShow=3D1; PPTSld.document.body.scroll=3D"no"; PPTSld.document.onkeypress=3DCloseWindow; PPTSld.document.onclick=3DCloseWindow; PPTSld.document.oncontextmenu=3D_CM; } function EndShow() { if( IsFramesMode() ) return if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue doc=3DPPTSld.document var dir =3D doc.body.dir if( dir !=3D "rtl" ) dir =3D "ltr"; doc.open() doc.writeln('<html><body dir=3D' + dir + ' bgcolor=3Dblack onload=3Dparent= .SetupEndShow() onunload=3Dparent.Unload()><center><p><font face=3DTahoma c= olor=3Dwhite size=3D2><br><b>' + ENDSHOW_MESG + '</b></font></p></center></= body></html>') doc.close() } function SetSldVisited(){ GetSldList().mList[gCurSld-1].mVisited=3Dtrue } function IsSldVisited(){ return GetSldList().mList[gCurSld-1].mVisited } function hrefList( sldHref, visible, advDelay, advClk ) { this.mSldHref=3D this.mNtsHref =3D sldHref this.mOrigVis=3D this.mVis =3D visible this.mVisited=3D false this.mAdvDelay=3D advDelay this.mAdvOnClk=3D advClk } function SldList(arr,curSld,fEnd) { this.mCurSld =3D curSld; this.mList =3D new Array(); var idx =3D 1; for(ii=3D0;ii<arr.length;ii++) { this.mList[ii] =3D new hrefList( arr[ii].mSldHref, arr[ii].mOrigVis, arr[= ii].mAdvDelay, arr[ii].mAdvOnClk ); if( arr[ii].mOrigVis ) this.mList[ii].mSldIdx =3D idx++; } this.mNumVisSlds =3D idx-1; this.fEndShow =3D fEnd; } function GetSldList() { return gSldStack[gSldStack.length-1] } function GetCurSld() { return parent.GetSldList().mList[parent.gCurSld - 1]= } gSldStack =3D new Array(); gSldStack[0] =3D new SldList(gMainDoc,gCurSld,1) function ToggleOtlPane() { frmset=3Ddocument.all("PPTHorizAdjust") frm=3Ddocument.all("PPTOtl") if( gOtlOpen ) frmset.cols=3D"*,100%" else frmset.cols=3D"25%,*" gOtlOpen=3D!gOtlOpen frm.noResize=3D!frm.noResize UpdOtNavPane() } function ToggleNtsPane() { frmset=3Ddocument.all("PPTVertAdjust") frm=3Ddocument.all("PPTNts") if( gNtsOpen ) frmset.rows=3D"100%,*" else frmset.rows=3D"*,20%" gNtsOpen=3D!gNtsOpen UpdNtsPane() } function ViewCustomShow(idx,fEnd) { if( !IsFullScrMode() ) return; var sldList =3D new Array(); var custShow =3D custShowList[idx-1]; var jj =3D 0; for( ii=3D0;ii<custShow.length;ii++ ) { if( custShow[ii] <=3D gMainDoc.length ) sldList[jj++] =3D gMainDoc[custShow[ii]-1]; } if (sldList.length > 0) { PushSldList(sldList,fEnd); gCurSld =3D 1; } else if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue } function PushSldList(arr,fEnd) { var ii =3D gSldStack.length; gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd); GoToSld( gSldStack[ii].mList[0].mSldHref ); } function PopSldList() { if (gSldStack[gSldStack.length-1].fEndShow) EndShow() else { gCurSld =3D gSldStack[gSldStack.length-1].mCurSld; gSldStack[gSldStack.length-1] =3D null; gSldStack.length--; var sldList =3D gSldStack[gSldStack.length-1]; GoToSld( sldList.mList[gCurSld - 1].mSldHref ); } } var custShowList=3Dnew Array(); function ImgBtn( oId,bId,w,action ) { var t=3Dthis t.Perform =3D _IBP t.SetActive =3D _IBSetA t.SetInactive=3D _IBSetI t.SetPressed =3D _IBSetP t.SetDisabled=3D _IBSetD t.Enabled =3D _IBSetE t.ChangeIcon =3D null t.UserAction =3D action t.ChgState =3D _IBUI t.mObjId =3D oId t.mBorderId=3D bId t.mWidth =3D w t.mIsOn =3D t.mCurState =3D 0 } function _IBSetA() { if( this.mIsOn ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _IBSetI() { if( this.mIsOn ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } function _IBSetP() { if( this.mIsOn ) { obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 ) obj.style.posLeft+=3D1; obj.style.posTop+=3D1 } } function _IBSetD() { obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 ) obj.style.posTop=3D0 } function _IBSetE( state ) { var t=3Dthis GetObj( t.mBorderId ).style.visibility=3D"visible" if( state !=3D t.mIsOn ) { t.mIsOn=3Dstate if( state ) t.SetInactive() else t.SetDisabled() } } function _IBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( t.ChangeIcon ) { obj=3DGetObj(t.mObjId) if( t.ChangeIcon() ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth else obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth } t.SetActive() } } function _IBUI( clr1,clr2,nextState ) { var t=3Dthis SetBorder( GetObj( t.mBorderId ),clr1,clr2 ) obj=3DGetObj( t.mObjId ) obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj= .style.posTop t.mCurState=3DnextState return obj } function TxtBtn( oId,oeId,action,chkState ) { var t=3Dthis t.Perform =3D _TBP t.SetActive =3D _TBSetA t.SetInactive=3D _TBSetI t.SetPressed =3D _TBSetP t.SetDisabled=3D _TBSetD t.SetEnabled =3D _TBSetE t.GetState =3D chkState t.UserAction =3D action t.ChgState =3D _TBUI t.mObjId =3D oId t.m_elementsId=3D oeId t.mIsOn =3D 1 } function _TBSetA() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gHiliteClr,gShadowClr,0,0 ) } function _TBSetI() { var t=3Dthis if( t.mIsOn && !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) } function _TBSetP() { if( this.mIsOn ) this.ChgState( gShadowClr,gHiliteClr,1,1 ) } function _TBSetD() { this.ChgState( gFaceClr,gFaceClr,0,0 ) this.mIsOn =3D 0 } function _TBSetE() { var t=3Dthis if( !t.GetState() ) t.ChgState( gFaceClr,gFaceClr,0,0 ) else t.ChgState( gShadowClr,gHiliteClr,1,1 ) t.mIsOn =3D 1 } function _TBP() { var t=3Dthis if( t.mIsOn ) { if( t.UserAction !=3D null ) t.UserAction() if( !t.GetState ) return if( t.GetState() ) t.SetPressed() else t.SetActive() } } function _TBUI( clr1,clr2,lOffset,tOffset ) { SetBorder( GetObj( this.mObjId ),clr1,clr2 ) Offset( GetObj( this.m_elementsId ),lOffset,tOffset ) } function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle= ft } function SetBorder( obj, upperLeft, lowerRight ) { s=3Dobj.style; s.borderStyle =3D "solid" s.borderWidth =3D 1 s.borderLeftColor =3D s.borderTopColor =3D upperLeft s.borderBottomColor=3D s.borderRightColor =3D lowerRight } function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] } function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() } function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() } function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() } function BtnOnUp() { b=3DGetBtnObj() if( b !=3D null ) b.Perform() else Upd() } function GetNtsState(){ return parent.gNtsOpen } function GetOtlState(){ return parent.gOtlOpen } function GetOtlTxtState(){ return parent.gOtlTxtExp } function NtsBtnSetFlag( fVal ) { s=3Ddocument.all.item( this.m_flagId ).style s.display=3D"none" if( fVal ) s.display=3D"" else s.display=3D"none" } function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etActive() } function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etInactive() } function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S= etPressed() } function _BSetA_BorderImg() { b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 ) obj.style.posTop=3D0 } } function _BSetI_BorderImg() { b =3D gBtnArr[this.mBorderId] if( b !=3D null && this.mIsOn && !b.GetState() ) { obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 ) obj.style.posTop=3D0 } } var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"= THREEDFACE" var gBtnArr =3D new Array() gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan= e,GetOtlState ) gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt= lPane,GetOtlState ) gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN= tsPane ) gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg; gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg; gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.= ToggleNtsPane,GetNtsState ) gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To= ggleNtsPane,GetNtsState ) gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n= b_prevBorder",30,parent.GoToPrevSld ) gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n= b_nextBorder",30,parent.GoToNextSld ) gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent= .FullScreen ) gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa= rent.FullScreen,null ) gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border; gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent= .FullScreen,null ) gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border; gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border; gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice= ","nb_voiceBorder",18,parent.ToggleVNarration ) gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT= xt","nb_otlTxtBorder",23,parent.ToggleOtlText ) gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts" gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState var sNext=3D"Další",sPrev=3D"Předchozí",sEnd=3D"Kon= ec prezentace",sFont=3D"Arial",sArrow=3D"Šipka",sFreeform=3D"Voln&yacu= te; tvar",sRect=3D"Obdélník",sOval=3D"Ovál" function ShowMenu() { BuildMenu(); var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y= =3DPPTSld.event.clientY+doc.scrollTop m =3D PPTSld.document.all.item("ctxtmenu") m.style.pixelLeft=3Dx if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) ) m.style.pixelLeft=3Dx-m.scrollWidth m.style.pixelTop=3Dy if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) ) m.style.pixelTop=3Dy-m.scrollHeight m.style.display=3D"" } function _CM() { if( !parent.IsFullScrMode() ) return; if(!PPTSld.event.ctrlKey) { ShowMenu() return false } else HideMenu() } function BuildMenu() { if( PPTSld.document.all.item("ctxtmenu") ) return var mObj=3DCreateItem( PPTSld.document.body ) mObj.id=3D"ctxtmenu" mObj.style.visibility=3D"hidden" var s=3DmObj.style s.position=3D"absolute" s.cursor=3D"default" s.width=3D"120px" SetCMBorder(mObj,"menu","black") var iObj=3DCreateItem( mObj ) SetCMBorder( iObj, "threedhighlight","threedshadow" ) iObj.style.padding=3D2 CreateMenuItem( iObj,sNext,M_GoNextSld,M_True ) CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld ) CreateSeparator( iObj ) CreateMenuItem( iObj,sEnd,M_End,M_True ) mObj.style.visibility=3D"visible" } function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa= lue=3Dfalse } function Highlight() { ChangeClr("activecaption","threedhighlight") } function Deselect() { ChangeClr("threedface","menutext") } function Perform() { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) e.Action() else PPTSld.event.cancelBubble=3Dtrue } function ChangeClr( bg,clr ) { e=3DPPTSld.event.srcElement if( e.type=3D=3D"menuitem" && e.IsActive() ) { e.style.backgroundColor=3Dbg e.style.color=3Dclr } } function M_HasPrevSld() { return( parent.HasPrevSld() ) } function M_GoNextSld() { if( gIsEndShow ) M_End(); 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snímek" style=3D'position:relative; left:-90px'></div> </div> </td> </table> </div> <div id=3DOtlNavObj onload=3D"Load()" onmouseover=3D"BtnOnOver()" onmousedown=3D"BtnOnDown()" onmouseout=3D"BtnOnOut()" onmouseup=3D"BtnOnUp(= )" onkeypress=3D"ExecBtn()" style=3D'display:none;visibility:hidden'> <table style=3D'position:relative;width:70px' align=3Dleft cellpadding=3D0 = cellspacing=3D0> <td nowrap><div title=3D"Zobrazit či skrýt osnovu" id=3D"nb_otl" onfocus=3D"BtnOnOver()" onblur= =3D"BtnOnOut()" TABINDEX=3D11 style=3D'position:absolute;top:0%;left:0%;width:100%;height:100%;cursor:de= fault'> <div id=3D"nb_otlElem" align=3Dcenter style=3D'position:relative;padding:3= px;font-family:Arial; color:buttontext;font-size:9pt'>Osnova</div></div> </td> </table> <table style=3D'position:relative' align=3Dcenter cellpadding=3D0 cellspaci= ng=3D0> <td> <div style=3D'position:absolute;left:-18px;width:24px;height:20px;border-s= tyle: solid;border-width:1px;border-color:threedface' onfocus=3D"BtnOnOver()" on= blur=3D"BtnOnOut()" TABINDEX=3D12 id=3D"nb_otlTxtBorder"> <div style=3D'position:absolute;clip:rect(0px, 22px, 18px, 0px)'><img src=3Dbuttons.gif id=3D"nb_otlTxt" title=3D"Sbalit či rozbalit osnovu" style=3D'position:relative;left:-157px'></div> </div> </td> </table> </div> <div id=3DOtlObj style=3D'display:none;visibility:hidden;'> <table width=3D"100%" style=3D'font-family:Arial;font-size:9pt'> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>1</font></div> </td> <td width=3D"100%"> <div id=3DPPTP1 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0001.htm');" id=3DPPTL1><br> INTERAKCE NEALELNÍCH GENŮ<br> <span style=3D'mso-spacerun:yes'> </span>POLYGENNÍ DĚDIČNOST</a></font></div> <div id=3DPPTC1 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <br> <li>© Aleš Panczak, ÚBLG 1. LF a VFN</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>2</font></div> </td> <td> <div id=3DPPTP2 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0004.htm');" id=3DPPTL2>Krátk&eac= ute; opakování:</a></font></div> <div id=3DPPTC2 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Jednotková dědičnost</li> <ul> <li>podíl alel téhož genu (lokusu) při utváření fenotypu hybrida</li> <li>rozdíly ve stupni dominance alel</li> </ul> <li>Alelní a nealelní geny</li> <li>Dihybridismus</li> <ul> <li>16tipolní tabulka genotypových kombinací</li> <li>genotypové a fenotypové štěpné poměry.</li> </ul> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>3</font></div> </td> <td> <div id=3DPPTP3 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0005.htm');" id=3DPPTL3>Úvod I:</= a></font></div> <div id=3DPPTC3 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>na genetické determinaci určitých znaků se spolupodílejí alely dvou, tří a více genů</li> <ul> <li>gény modifikátory, modifikátorové gény - určité gény jen pozměňují (modifikují) stupeň projevu jiných nealelních genů</li> <li>genová interakce - pokud alely určitých genů zcela zásadně mění fenotypový účinek alel jiných genů, znak vzniká spolupůsobením dvou nebo více nealelních genů</li> </ul> <li>geny komplementární, epistatické nebo suplementární - podle toho, jak rovnoměrně se jednotlivé geny na výsledném fenotypu uplatňují, přehled v tabulkách na str. 47 a = 48Kot.</li> <li>význam modelových příkladů z rostlinné a zejména savčí genetiky – u člověka je analýza situace komplikovanější.</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>4</font></div> </td> <td> <div id=3DPPTP4 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0007.htm');" id=3DPPTL4>Bombayský= fenotyp v systému ABO<br> <span style=3D'mso-spacerun:yes'> </span>př. 6/s= tr. 50 Kot</a></font></div> <div id=3DPPTC4 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>Závěr: suplementarita, recesivní epistáze, příklad metabolického řetězce.</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>5</font></div> </td> <td> <div id=3DPPTP5 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0003.htm');" id=3DPPTL5><span style=3D'mso-spacerun:yes'> </span></a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>6</font></div> </td> <td> <div id=3DPPTP6 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0015.htm');" id=3DPPTL6>Úvod II:<= br> Rekapitulace základních pojmů</a></font></div> <div id=3DPPTC6 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>multifaktoriální znaky</li> <li>polygenní dědičnost</li> <li>major a minor gény</li> <li>gény-modifikátory</li> <li>aktivní a neaktivní alely</li> <li>aditivní účinek alel</li> <li>variabilita podmíněná genotypem a<span style=3D'mso-spacerun:yes'> </span>prostředím</li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>7</font></div> </td> <td> <div id=3DPPTP7 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0017.htm');" id=3DPPTL7>Odvození štěpných poměrů<br> Pascalův trojúhelník</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>8</font></div> </td> <td> <div id=3DPPTP8 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0016.htm');" id=3DPPTL8>Odvození štěpných poměrů pro n alel<br> př. 9/str. 50 Kot</a></font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>9</font></div> </td> <td> <div id=3DPPTP9 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0019.htm');" id=3DPPTL9>Orientačn&i= acute; stanovení rizika u polygenní dědičnosti</a></font= ></div> <div id=3DPPTC9 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>O multifaktoriální etiologii lze uvažovat, kdy= 82; má choroba zjevně familiální výskyt, avšak nelze jednoznačně určit typ dědičnosti v rodině</li> <li>Riziko pro příbuzné I. stupně je přibližně odmocninou z rizika populačního (incidence) – Edwardsův vzorec</li> <li>Riziko je podstatně nižší pro příbuzné II. stupně, pro vzdálenější příbuzné klesá již méně rychle</li> <li>Riziko je vyšší, když je postiženo více členů rodiny – pro příbuzné I. stupně se hodnota vypočtená podle Edwardsova vzorce násobí 2= , 3 apod.</li> <li>Čím těžší je postižení či dřívější manifestace tím vyšší je riziko opakování</li> <li>Zvýšené riziko opakování v rodinách, kde jsou rodiče pokrevně příbuznými</li> <li>Výrazný je podíl faktorů (zevního) prostředí</li> <li>Pokud je sledovaný znak častější u jedn= oho pohlaví než u druhého, pak je riziko opakování vyšší pro příbuzné pacienta, který je pří= ;slušníkem méně často postiženého pohlaví.<= /li> </ul> </font></div> </td> </tr> <tr onmouseover=3D"Over(this)" onmouseout=3D"Out(this)" onclick=3D"Follow(= this)" style=3D'cursor:hand'> <td align=3Dright valign=3Dtop> <div class=3DsldNum><font size=3D2>10</font></div> </td> <td> <div id=3DPPTP10 class=3DPTxt><font size=3D2><a href=3D"javascript:GoToSld('slide0020.htm');" id=3DPPTL10>Riziko rozštěpu neurální trubice<br> Úkol č. 15/str 52 Kot</a></font></div> <div id=3DPPTC10 class=3DCTxt style=3D'display:none'><font size=3D2> <ul> <li>VVV s multifaktoriální etiologií a polygenn&iac= ute; 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