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Klepnutím lze upravit styl =
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Klepnutím lze upravit styl =
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Klepnutím lze upravit styl =
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II. ročn&iacu=
te;k,
zimní semestr
3. týden <= span style=3D'mso-tab-count:1;width:7.09%'> 20.1= 0. - 24.10.2008
3. týden <= span style=3D'mso-tab-count:1;width:7.09%'> 20.1= 0. - 24.10.2008
P O P U L A Č N Í G E N E T I K A
I I .
<=
span
style=3D'font-family:Arial;font-size:156%;color:yellow;mso-color-index:3'>=
•Odhady genov&yacut=
e;ch
frekvencí – rozdíl postupu výpočtu při
<=
span
style=3D'font-family:Arial;font-size:156%;color:yellow;mso-color-index:3'>=
vtřech distinktních fenotypech (např. systém MN).
v
v
v
<=
span
style=3D'font-family:Arial;font-size:156%;color:yellow;mso-color-index:3'>=
vúplné dominanci (Rh systém, ne/chutnačstv&iac=
ute;
PTC
nebo AR choroby)
2
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vzorku
jedinců ve
počet všech
2
)
(
tů
heterozygo
počet
)
(
homozygotů
počet
2
+=
=3D=
Aa
AA
p(=
A)
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populaci
v
frekvence
vzorku
ve
osob
počet všech
homozygotů
recesivních
počet
=3D=
=3D
=3D=
q
<=
span
style=3D'font-family:Arial;font-size:156%;color:yellow;mso-color-index:3'>=
•<=
/span>Selekce=
<=
span
style=3D'font-family:Arial;font-size:156%;color:yellow;mso-color-index:3'>=
vproti recesivním homozygotům (zpočátk=
u rychlý, pak
zpomalující se pokles frekvence recesívn&iacut=
e;
alely, většina alel je v heterozygotech, paradoxní
výsledek při nevhodné aplikaci modelu selekce)
=
3
P=
reference
heterozygotů - úkol č. 20/str. 1=
07 Kot
![](3D"slide0119_image004.gif")
![](3D"slide0119_image006.gif")
24
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![](3D"slide0119_image010.gif")
4
P=
reference
heterozygotů - úkol č. 20/str. 1=
07 Kot
Interpretace <=
/span>c2 (chí kvadrát) testu:=
výskyt (nalezené četnosti) =
jednotlivých
genotypů a jejich (dle C-H-W rovnováhy) =
počty
očekávané jsou statisticky významně
odlišné – lze proto předpokládat, že
tento vzorek je v rovnováze =
vyvolané
jinými mechanismy než C-H-W rovnováhou.
![](3D"slide0122_image012.gif")
![](3D"slide0122_image014.gif")
5
b) odhady
selekčních koeficientů s1 a s2
reprodukčn&ia=
cute;
schopnosti jednotlivých genotypů
![](3D"slide0121_image015.gif")
s1 =3D 1 – w1 =3D 1 - 0.879 =3D 0.121
=
3;
s2 =3D 1 – w2 =3D 1 - 0.138 =3D 0.862
6
P=
reference
heterozygotů - úkol č. 20/str. 1=
07 Kot
s1 a s2 jako doplňky
relativních reprodukčních schopností =
do
1.
![](3D"slide0121_image017.gif")
přepočet=
na
relativní reprodukční schopnosti po vydělení=
; reprodukčn&ia=
cute;
schopností nejplodnějšího genotypu
![](3D"slide0121_image019.gif")
![](3D"slide0069_image020.gif")
Srpkovitá
anémie jako stabilní polymorfismus v důsledku
preference heterozygotů
2. Výsledek
domácího úkolu IV
Preference
heterozygotů - úkol č.
20/str. 107 Kot
7
a) pro AR gen<=
/span>
Selekce proti
recesivním homozygotům
3. Mutačně-=
selekční
rovnováha I
![](3D"slide0123_image022.gif")
![](3D"slide0123_image024.gif")
![](3D"slide0123_image026.gif")
![](3D"slide0123_image027.gif")
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![](3D"slide0123_image033.gif")
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8
Mutace<=
span
style=3D'font-family:"Arial CE";mso-ascii-font-family:"Arial CE";mso-hansi=
-font-family:
"Arial CE";font-size:133%;color:yellow;mso-color-index:3;mso-special-forma=
t:
lastCR;display:none'>
pro
vzácná onemocnění je q velmi malé,
proto
A
a
=
m
Rovnováha
Þ Þ Þ
a) pro AR gen<=
/span>
Odhad
mutační intenzity m pro cystickou fibrózu =
(mukoviscidó=
;zu)
- příklad není ve skriptech
9
Rovnováha
![](3D"slide0124_image039.gif")
Þ Þ Þ
![](3D"slide0124_image041.gif")
saa =3D 1
qrovnov. <=
span
style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-hansi-font-fami=
ly:
Arial;font-size:133%;color:yellow;mso-color-index:3'>=3D 1/50
<=
/span>
m =3D ???
![](3D"slide0124_image042.gif")
Mutace =
;
Selekce
A
a
m =
;
saa
a
![](3D"slide0124_image044.gif")
b) pro AD gen<=
/span>
Selekce proti
dominantnímu fenotypu
3. Mutačně-=
selekční
rovnováha III
![](3D"slide0125_image046.gif")
![](3D"slide0125_image048.gif")
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![](3D"slide0125_image065.gif")
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Populační genetika 2
3. Mutačně-=
selekční
rovnováha IV
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Populační genetika 2
3. Mutačně-=
selekční
rovnováha V
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Populační genetika 2
![3D"MPj01779070000[1]"](3D"slide0127_image076.jpg")
• vždy 6 hod=
ů
- výsledky série zaznamenat
• podle
dosaženého výsledku (poměru) <=
/b>pA / qa změnit pravidlo pro
následující sérii hodů
(generaci)
• pokračujte=
do
stádia fixace=
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Populační genetika 2
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Populační genetika 2
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Populační genetika 2
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Populační genetika 2
Z=
adání:
samostatně úkol č. 33/str. 113 Kot
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běloši
( p )
0,03
černoši
afričtí (=
pi )
0,63
černoši
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Populační genetika 2
7. Závěr
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FullScrInit();
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}
}
function MakeSldVis()
{
var fTrans=3Dg_showAnimation && SldHasTrans()
if( fTrans )
{
if( g_bgSound ) {
idx=3Dg_bgSound.indexOf(",");
pptSound.src=3Dg_bgSound.substr( 0, idx );
pptSound.loop=3D -(parseInt(g_bgSound.substr(idx+1)));
}
SlideObj.filters.revealtrans.Apply()
}
SlideObj.style.visibility=3D"visible"
if( fTrans )
SlideObj.filters.revealtrans.Play()
}
function MakeNotesVis()
{
if( !IsNts() ) return false
SlideObj.style.display=3D"none"
nObj =3D document.all.item("NotesObj")
parent.SetHasNts(0)
if( nObj ) {
nObj.style.display=3D""
parent.SetHasNts(1)
}
return 1
}
function ChkAutoAdv()
{
if(SldHasTrans())
SlideObj.onfilterchange=3DAutoAdv
else
AutoAdv()
}
function AutoAdv()
{
if(!IsWin("PPTSld") || !gUseSldTimings )return
var sld=3DGetCurSld()
if( (sld.mAdvDelay>0) && !parent.IsFramesMode() )
setTimeout("parent.GoToNextSld()",sld.mAdvDelay)
}
function GetObj(id)
{
if(g_supportsPPTHTML) return document.all(id);
else return document.getElementById(id);
}
function SldHasTrans() { return SlideObj.style.filter !=3D ""; }
function GetSldId() { return sId=3Dlocation.href.substring(location.href.la=
stIndexOf('/')+1) }
function HideMenu() { if( frames["PPTSld"] && PPTSld.document.all.item("ctx=
tmenu") && PPTSld.ctxtmenu.style.display!=3D"none" ) { PPTSld.ctxtmenu.styl=
e.display=3D'none'; return true } return false }
function IsWin( name ) { return window.name =3D=3D name }
function IsNts() { return IsWin("PPTNts") }
function IsSldOrNts() { return( IsWin("PPTSld")||IsWin("PPTNts") ) }
function SupportsPPTAnimation() { return( navigator.platform =3D=3D "Win32"=
&& navigator.appVersion.indexOf("Windows")>0 ) }
function SupportsPPTHTML()
{
var appVer=3Dnavigator.appVersion, msie=3DappVer.indexOf("MSIE "), ver=3D0
if( msie >=3D 0 )
ver=3DparseFloat( appVer.substring( msie+5, appVer.indexOf(";",msie) ) )
else
ver=3DparseInt(appVer)
return( ver >=3D 4 && msie >=3D 0 )
}
function _RSW()
{
if( !g_supportsPPTHTML || IsNts() ||
( !g_scaleInFrame && (!IsWin("PPTSld") || !parent.IsFullScrMode()) ) )
return
var padding=3D0;
if( IsWin("PPTSld") && parent.IsFramesMode() ) padding=3D6
cltWidth=3Ddocument.body.clientWidth-padding
cltHeight=3Ddocument.body.clientHeight-padding
factor=3D(1.0*cltWidth)/g_origW
if( cltHeight < g_origH*factor )
factor=3D(1.0*cltHeight)/g_origH
newSize =3D g_origSz * factor
if( newSize < 1 ) newSize=3D1
s=3DSlideObj.style
s.fontSize=3DnewSize+"px"
s.posWidth=3Dg_origW*factor
s.posHeight=3Dg_origH*factor
s.posLeft=3D(cltWidth-s.posWidth+padding)/2
s.posTop=3D(cltHeight-s.posHeight+padding)/2
if( g_scaleHyperlinks )
ScaleHyperlinks( factor )
}
function _InitAnimations()
{
animRuntimeInstalled =3D ''+document.body.localTime !=3D 'undefined';
isFullScreen =3D (window.name =3D=3D "PPTSld") && !parent.IsFramesMode();
g_animUseRuntime =3D g_showAnimation && animRuntimeInstalled && !(isFullSc=
reen && parent.IsSldVisited());
if( g_animUseRuntime ) {
collSeq =3D document.all.tags("seq");
if( collSeq !=3D null ) {
for(ii=3D0;ii numSlds )
gSldJumpIdx =3D numSlds;
if ( gSldJumpIdx >=3D 0 ) {
if ( gSldJumpIdx =3D=3D 0 )
gSldJumpIdx =3D 1;
var jumpTo =3D parseInt(gSldJumpIdx);
gSldJump =3D 0; gSldJumpIdx =3D "";
win.GoToSld( parent.GetSldList().mList[jumpTo-1].mSldHref )
}
}
}
function _KDH()
{
if( event.keyCode =3D=3D 8 ) {
event.returnValue =3D 0;
parent.GoToPrevSld();
}
}
function DocumentOnClick()
{
if( IsNts() || parent.HideMenu() ) return;
if( ( g_allowAdvOnClick && (window.name=3D=3D"PPTSld") && !parent.IsFrames=
Mode() ) ||
(event && event.keyCode=3D=3D32) ) {
if( g_animUseRuntime && g_animMainSequence && g_animMainSequence.cangonex=
t )
return;
parent.GoToNextSld();
}
}
var g_supportsPPTHTML =3D SupportsPPTHTML(), g_scaleInFrame =3D 1, gId=3D""=
, g_bgSound=3D"",
g_scaleHyperlinks =3D false, g_allowAdvOnClick =3D 1, g_showInBrowser =
=3D 0, gLoopCont =3D 0, gUseSldTimings =3D 1;
var g_showAnimation =3D g_supportsPPTHTML && SupportsPPTAnimation() && ( (w=
indow.name=3D=3D"PPTSld" && !parent.IsFramesMode()) || g_showInBrowser );va=
r g_animManager =3D null;
var g_animUseRuntime =3D false;
var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime;
var g_animMainSequence =3D null;
var ENDSHOW_MESG=3D"Konec prezentace, klepnutím ukončíte=
předvádění.", SCREEN_MODE=3D"Frames", gIsEndShow=
=3D0, NUM_VIS_SLDS=3D23, SCRIPT_HREF=3D"script.js", FULLSCR_HREF=3D"fullscr=
een.htm";
var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO=
tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true
window.gPPTHTML=3DSupportsPPTHTML()
var gMainDoc=3Dnew Array(new hrefList("slide0001.htm",1,-1,1),new hrefList(=
"slide0065.htm",1,-1,1),new hrefList("slide0118.htm",1,-1,1),new hrefList("=
slide0119.htm",1,-1,1),new hrefList("slide0122.htm",1,-1,1),new hrefList("s=
lide0121.htm",1,-1,1),new hrefList("slide0069.htm",1,-1,1),new hrefList("sl=
ide0123.htm",1,-1,1),new hrefList("slide0124.htm",1,-1,1),new hrefList("sli=
de0125.htm",1,-1,1),new hrefList("slide0126.htm",1,-1,1),new hrefList("slid=
e0072.htm",1,-1,1),new hrefList("slide0127.htm",1,-1,1),new hrefList("slide=
0074.htm",1,-1,1),new hrefList("slide0128.htm",1,-1,1),new hrefList("slide0=
133.htm",1,-1,1),new hrefList("slide0078.htm",1,-1,1),new hrefList("slide01=
35.htm",1,-1,1),new hrefList("slide0131.htm",1,-1,1),new hrefList("slide013=
2.htm",1,-1,1),new hrefList("slide0087.htm",1,-1,1),new hrefList("slide0093=
.htm",1,-1,1),new hrefList("slide0097.htm",1,-1,1));
function FullScrInit()
{
g_allowAdvOnClick =3D GetCurSld().mAdvOnClk
document.body.style.backgroundColor=3D"black"
document.oncontextmenu=3Dparent._CM;
document.onkeydown =3D _KDH;
document.ondragstart=3DCancel
document.onselectstart=3DCancel
self.focus()
}
function Redirect( frmId )
{
var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId()
if(idx>=3D0) str=3Dstr.substr(1);
if( window.name !=3D frmId && ( sId !=3D str) ) {
obj =3D GetObj("Main-File")
window.location.href=3Dobj.href+"#"+sId
return 1
}
return 0
}
var MHTMLPrefix =3D CalculateMHTMLPrefix();
function CalculateMHTMLPrefix()
{
if ( document.location.protocol =3D=3D 'mhtml:') {
href=3Dnew String(document.location.href)
Start=3Dhref.indexOf('!')+1
End=3Dhref.lastIndexOf('/')+1
if (End < Start)
return href.substring(0, Start)
else
return href.substring(0, End)
}
return '';
}
function GetTags(base,tag)
{
if(g_supportsPPTHTML) return base.all.tags(tag);
else return base.getElementsByTagName(tag);
}
function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP=
refix+GetHrefObj( gCurSld ).mNtsHref ) }
function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() }
function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() }
function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() }
function SetHasNts( fVal )
{
if( gHasNts !=3D fVal ) {
gHasNts=3DfVal
UpdNavPane()
}
}
function ToggleOtlText()
{
gOtlTxtExp=3D!gOtlTxtExp
UpdOtlPane()
}
function ClearMedia()
{
if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0;
}
function FullScreen()
{
if ( PPTSld.g_animUseRuntime )
PPTSld.document.body.pause();
ClearMedia();
var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF =
: FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref;
if(PPTNav.event.ctrlKey) {
var w =3D (window.screen.availWidth * 1.0) / 2.0
var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW
win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top=
=3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h );
if( win.document.body && PPTSld.g_animUseRuntime )
win.document.body.PPTSldFrameset=3Dwindow;
}
else
{
win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" );
if( win.document.body && PPTSld.g_animUseRuntime )
win.document.body.PPTSldFrameset=3Dwindow;
}
}
function ToggleVNarration()
{
rObj=3DPPTSld.document.all("NSPlay")
if( rObj && !PPTSld.g_animUseRuntime ) {
if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) )
rObj.Play()
else if( rObj.playState =3D=3D 2 )
rObj.Pause()
else
return;
}
else if( PPTSld.g_animUseRuntime )
{
narObj =3D PPTSld.document.all("narrationID")
if( narObj )
narObj.togglePause()
}
}
function GetCurSldNum()
{
obj=3DGetHrefObj(gCurSld)
if( obj.mOrigVis =3D=3D 1 )
return obj.mSldIdx
else
return gCurSld
}
function GetNumSlds()
{
if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 )
return GetSldList().mNumVisSlds;
else
return GetSldList().mList.length
}
function GetSldNum( href )
{
for(ii=3D0; ii 1 )
PopSldList();
else if( !IsFramesMode() ) {
if( gLoopCont )
GoToFirst()
else
EndShow()
}
}
function GoToPrevSld()
{
ii=3DgCurSld-1
if( ii > 0 ) {
obj=3DGetHrefObj(ii)
while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) )
obj=3DGetHrefObj(--ii)
if( ii =3D=3D 0 ) ii=3D1
GoToSldNum(ii)
}
}
function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) }
function GoToLast()
{
ii=3DGetSldList().mList.length
if( ii !=3D gCurSld )
GoToSld( GetHrefObj(ii).mSldHref )
}
function GoToSldNum( num )
{
if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue
obj =3D GetHrefObj( num )
obj.mVis=3D1
gPrevSld=3DgCurSld
gCurSld =3D num;
PPTSld.location.replace(MHTMLPrefix+obj.mSldHref)
if( IsFramesMode() ) {
UpdNavPane(); UpdOtlPane(); UpdNtsPane()
}
}
function GoToSld( href )
{
if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue
GetHrefObj( GetSldNum(href) ).mVis=3D1
PPTSld.location.replace(MHTMLPrefix+href)
}
function SldUpdated( id )
{
if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return
gPrevSld=3DgCurSld
gCurSld=3DGetSldNum(id)
if( IsFramesMode() ) {
UpdNavPane(); UpdOtlPane(); UpdNtsPane()
}
}
function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) }
function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO=
bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) }
function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) }
function CloseWindow() {
if( HideMenu() ) return;
var event =3D PPTSld.event;
if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D=
=3D32 || event.type=3D=3D"click" ) )
window.close( self );
CatchNumKeys( self, event );
}
function Unload() { gIsEndShow=3D0; }
function SetupEndShow() {
gIsEndShow=3D1;
PPTSld.document.body.scroll=3D"no";
PPTSld.document.onkeypress=3DCloseWindow;
PPTSld.document.onclick=3DCloseWindow;
PPTSld.document.oncontextmenu=3D_CM;
}
function EndShow()
{
if( IsFramesMode() ) return
if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue
doc=3DPPTSld.document
var dir =3D doc.body.dir
if( dir !=3D "rtl" ) dir =3D "ltr";
doc.open()
doc.writeln(' 0) {
PushSldList(sldList,fEnd);
gCurSld =3D 1;
}
else
if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue
}
function PushSldList(arr,fEnd) {
var ii =3D gSldStack.length;
gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd);
GoToSld( gSldStack[ii].mList[0].mSldHref );
}
function PopSldList() {
if (gSldStack[gSldStack.length-1].fEndShow)
EndShow()
else {
gCurSld =3D gSldStack[gSldStack.length-1].mCurSld;
gSldStack[gSldStack.length-1] =3D null;
gSldStack.length--;
var sldList =3D gSldStack[gSldStack.length-1];
GoToSld( sldList.mList[gCurSld - 1].mSldHref );
}
}
var custShowList=3Dnew Array();
function ImgBtn( oId,bId,w,action )
{
var t=3Dthis
t.Perform =3D _IBP
t.SetActive =3D _IBSetA
t.SetInactive=3D _IBSetI
t.SetPressed =3D _IBSetP
t.SetDisabled=3D _IBSetD
t.Enabled =3D _IBSetE
t.ChangeIcon =3D null
t.UserAction =3D action
t.ChgState =3D _IBUI
t.mObjId =3D oId
t.mBorderId=3D bId
t.mWidth =3D w
t.mIsOn =3D t.mCurState =3D 0
}
function _IBSetA()
{
if( this.mIsOn ) {
obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 )
obj.style.posTop=3D0
}
}
function _IBSetI()
{
if( this.mIsOn ) {
obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 )
obj.style.posTop=3D0
}
}
function _IBSetP()
{
if( this.mIsOn ) {
obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 )
obj.style.posLeft+=3D1; obj.style.posTop+=3D1
}
}
function _IBSetD()
{
obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 )
obj.style.posTop=3D0
}
function _IBSetE( state )
{
var t=3Dthis
GetObj( t.mBorderId ).style.visibility=3D"visible"
if( state !=3D t.mIsOn ) {
t.mIsOn=3Dstate
if( state )
t.SetInactive()
else
t.SetDisabled()
}
}
function _IBP()
{
var t=3Dthis
if( t.mIsOn ) {
if( t.UserAction !=3D null )
t.UserAction()
if( t.ChangeIcon ) {
obj=3DGetObj(t.mObjId)
if( t.ChangeIcon() )
obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth
else
obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth
}
t.SetActive()
}
}
function _IBUI( clr1,clr2,nextState )
{
var t=3Dthis
SetBorder( GetObj( t.mBorderId ),clr1,clr2 )
obj=3DGetObj( t.mObjId )
obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj=
.style.posTop
t.mCurState=3DnextState
return obj
}
function TxtBtn( oId,oeId,action,chkState )
{
var t=3Dthis
t.Perform =3D _TBP
t.SetActive =3D _TBSetA
t.SetInactive=3D _TBSetI
t.SetPressed =3D _TBSetP
t.SetDisabled=3D _TBSetD
t.SetEnabled =3D _TBSetE
t.GetState =3D chkState
t.UserAction =3D action
t.ChgState =3D _TBUI
t.mObjId =3D oId
t.m_elementsId=3D oeId
t.mIsOn =3D 1
}
function _TBSetA()
{
var t=3Dthis
if( t.mIsOn && !t.GetState() )
t.ChgState( gHiliteClr,gShadowClr,0,0 )
}
function _TBSetI()
{
var t=3Dthis
if( t.mIsOn && !t.GetState() )
t.ChgState( gFaceClr,gFaceClr,0,0 )
}
function _TBSetP()
{
if( this.mIsOn )
this.ChgState( gShadowClr,gHiliteClr,1,1 )
}
function _TBSetD()
{
this.ChgState( gFaceClr,gFaceClr,0,0 )
this.mIsOn =3D 0
}
function _TBSetE()
{
var t=3Dthis
if( !t.GetState() )
t.ChgState( gFaceClr,gFaceClr,0,0 )
else
t.ChgState( gShadowClr,gHiliteClr,1,1 )
t.mIsOn =3D 1
}
function _TBP()
{
var t=3Dthis
if( t.mIsOn ) {
if( t.UserAction !=3D null )
t.UserAction()
if( !t.GetState )
return
if( t.GetState() )
t.SetPressed()
else
t.SetActive()
}
}
function _TBUI( clr1,clr2,lOffset,tOffset )
{
SetBorder( GetObj( this.mObjId ),clr1,clr2 )
Offset( GetObj( this.m_elementsId ),lOffset,tOffset )
}
function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle=
ft }
function SetBorder( obj, upperLeft, lowerRight )
{
s=3Dobj.style;
s.borderStyle =3D "solid"
s.borderWidth =3D 1
s.borderLeftColor =3D s.borderTopColor =3D upperLeft
s.borderBottomColor=3D s.borderRightColor =3D lowerRight
}
function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] }
function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() }
function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() }
function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() }
function BtnOnUp()
{
b=3DGetBtnObj()
if( b !=3D null )
b.Perform()
else
Upd()
}
function GetNtsState(){ return parent.gNtsOpen }
function GetOtlState(){ return parent.gOtlOpen }
function GetOtlTxtState(){ return parent.gOtlTxtExp }
function NtsBtnSetFlag( fVal )
{
s=3Ddocument.all.item( this.m_flagId ).style
s.display=3D"none"
if( fVal )
s.display=3D""
else
s.display=3D"none"
}
function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S=
etActive() }
function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S=
etInactive() }
function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S=
etPressed() }
function _BSetA_BorderImg()
{
b =3D gBtnArr[this.mBorderId]
if( b !=3D null && this.mIsOn && !b.GetState() ) {
obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 )
obj.style.posTop=3D0
}
}
function _BSetI_BorderImg()
{
b =3D gBtnArr[this.mBorderId]
if( b !=3D null && this.mIsOn && !b.GetState() ) {
obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 )
obj.style.posTop=3D0
}
}
var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"=
THREEDFACE"
var gBtnArr =3D new Array()
gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan=
e,GetOtlState )
gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt=
lPane,GetOtlState )
gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN=
tsPane )
gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg;
gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg;
gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.=
ToggleNtsPane,GetNtsState )
gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To=
ggleNtsPane,GetNtsState )
gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n=
b_prevBorder",30,parent.GoToPrevSld )
gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n=
b_nextBorder",30,parent.GoToNextSld )
gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent=
.FullScreen )
gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa=
rent.FullScreen,null )
gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border;
gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border;
gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent=
.FullScreen,null )
gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border;
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------=_NextPart_01C945D8.5C0936D0
Content-Location: file:///C:/E518CE38/POP208_soubory/fullscreen.htm
Content-Transfer-Encoding: quoted-printable
Content-Type: text/html; charset="us-ascii"
Populační genetika 2
10
pro
vzácná AD onemocnění je p velmi malé,
proto
Mutace<=
span
style=3D'font-family:"Arial CE";mso-ascii-font-family:"Arial CE";mso-hansi=
-font-family:
"Arial CE";font-size:133%;color:yellow;mso-color-index:3;mso-special-forma=
t:
lastCR;display:none'>
a
A
n
Rovnováha
Þ Þ Þ
b) pro AD gen - úkol č.
24/str, 109 Kot
Chondrodystrofie,
dnes se užívá název achondroplázie
• výskyt 1 / 50 000
<=
/span>
• plodnost 8 % plodnosti
zdravých
• ?? mutační
intenzita a Þ A
11
Přísně vzato, nejedná se o úplnou
dominanci, homozygotní potomci dvou postižených js=
ou
ještě více postižení.
<=
/div>
Jedinci s achondroplasií jsou heterozygoté,
představují 2pq, protože je však =
p velmi malé a
tedy =
;
, proto 2p.
<=
/b>
Mutace<=
span
style=3D'font-family:"Arial CE";mso-ascii-font-family:"Arial CE";mso-hansi=
-font-family:
"Arial CE";font-size:133%;color:yellow;mso-color-index:3;mso-special-forma=
t:
lastCR;display:none'>
a
A
n
2p
=3D 1
/ 50 000, z toho p =3D 1 / 100 000
s =3D 1 - w =3D 1 - 0,08 =3D 0,92
![](3D"slide0126_image068.gif")
![](3D"slide0126_image070.gif")
![](3D"slide0126_image072.gif")
![](3D"slide0126_image073.gif")
![](3D"slide0126_image075.gif")
Þ Þ Þ
K=
omentář:
o=
dhad
plodnosti naráží (obecně) na četné =
m=
etodologické
obtíže; frekvence chondrodystrofie <=
span
style=3D'font-size:75%;font-style:normal;color:yellow;mso-color-index:3'>z=
de
byla pozměněna pro snadnější výpoče=
t.
b) pro AD gen - úkol č.
24/str, 109 Kot
12
4.
Jednoduchý model genového driftu
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•modelujeme
náhodný výběr alel (gamet)
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•náhodov&=
yacute;
mechanismus – hod hrací kostkou
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•základn&=
iacute;
populace p =3D q =3D ½
Drift (posun) - změny genových
frekvencí v malých populacích vyvolané
náhodnými procesy
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•výbě=
;r
alely A … padne-li strana 1, 2 nebo 3
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•výbě=
;r
alely a … padne-li strana 4, 5 nebo 6
13
4. Jednoduchý model genového driftu II<=
br>
-
úkol č. 31/str. 111 Kot
•do protokolu připravit
záznamovou tabulku, alespoň do 10. generace
14
4. Jednoduchý model genového driftu III=
- úkol č. 31/str. 111 Kot
- úkol č. 31/str. 111 Kot
•Příklad výsledku=
po
první sérii hodů a změna pravidla pro
další sérii
15
4. Jednoduch&yacu=
te;
model genového driftu IV
- úkol č. 31/str. 111 Kot
- úkol č. 31/str. 111 Kot
•Příklad výsledku=
po
druhé sérii hodů a změna pravidla pro
další sérii
16
-=
pra=
cujte ve
dvojicích, jeden začne házet kostkou, druhý zapisuje
- pamatujte na změnu pravidla,= kdy podle dosaženého výsledku se v následující sérii hodů měn&iacu= te; genové frekv= ence a tedy, které strany kostky představují alelu A čia
- pokračujte
v pokusu až do stadia fixace
- nyní si vyměňte úlohy, takto jedna dvojice provede a zhodnotí alespoň dva pokusy, vý= sledky můžete graficky znázornit
- pro celou rotundu vypočítejte průměrnou dobu fixace jako vážený průměr výsledků všech dílčích pokusů, poměr fixovaných alel A a a by měl být přibližně 1 : 1
- pamatujte na změnu pravidla,= kdy podle dosaženého výsledku se v následující sérii hodů měn&iacu= te; genové frekv= ence a tedy, které strany kostky představují alelu A či
- nyní si vyměňte úlohy, takto jedna dvojice provede a zhodnotí alespoň dva pokusy, vý= sledky můžete graficky znázornit
- pro celou rotundu vypočítejte průměrnou dobu fixace jako vážený průměr výsledků všech dílčích pokusů, poměr fixovaných alel A a a by měl být přibližně 1 : 1
Pozn. k textu ve sk=
riptu:
počet ok (oko, mn. č. oka) =3D počet bodů či
teček na jednotlivých stranách/stěnách kost=
ky.
4. Jednoduchý
model genového driftu V
- úkol č. 31/str. 111 Kot
- úkol č. 31/str. 111 Kot
17
4. Jednoduch&yacu=
te;
model genového driftu VI
- úkol č. 31/str. 111 Kot
- úkol č. 31/str. 111 Kot
•Souhrn pokusu
18
5.
Koeficient inbredu=
F
Koeficient inbredu=
F
AB
CD
**
AC, AD
<=
/span>
BC, BD
A*
B*
C*
D*=
3;
AC, AD
<=
/span>
BC, BD
**
A*
B*
C*
D*=
3;
AA
BB
CC
DD
8x A*
8x B*
8x C*
8x D*
16x **=
3;
2x AB
2x AC
2x AD
2x BC
2x BD
2x CD
4x{=
3;
}60x=
19
5.
Koeficient příbuznosti
r
Koeficient příbuznosti
r
AB
CD
**
AC, AD
<=
/span>
BC, BD
AC, AD
<=
/span>
BC, BD
**
20
5. Koeficienty inbredu (F) a
příbuznosti (r<=
/b>)
<=
span
style=3D'font-size:88%;color:yellow;mso-color-index:3;font-weight:normal;
font-style:normal'>•podle ”hesla” jeden (F)=
vs.
dva genomy (r), ve vzorci pro r
vyjadřuje exponent n počet s=
pojových
čar rodokmenového schematu.
<=
span
style=3D'font-size:88%;color:yellow;mso-color-index:3;font-weight:normal;
font-style:normal'>•Zadání: úkoly č.=
28
a 29/str. 110 Kot samostatně ze skript,
nejlépe oba současně.
<=
span
style=3D'font-size:88%;color:yellow;mso-color-index:3;font-weight:normal;
font-style:normal'>•Řešení č. 28: koefic=
ient
inbredu pro potomka ze svazku nevlastního
strýce s neteří je 1/16
•<=
/span>&=
#344;ešení
č. 29: děti, které mají jednoho s=
polečného
rodiče, mají pravděpodobnost 1=
/4,
že namátkově vybraná alela sledovaného l=
okusu
je u nich shodná původem, proto děti, k=
teré
mají oba dva rodiče společné, mají <=
/span>p=
ravděpodobnost
2 x 1/4 =3D 1/2, že namátkově v=
ybraná
alela sledovaného lokusu je u nich s=
hodná
původem.
21
6. Migrace
22
•<=
/span>D=
omácí
příprava: úkol č. 27/str. 119 Kot (=
změny
poměru pohlaví – indukované m=
utace
u ozářených)
•<=
/span>
•Domácí
studium – test v příštím
týdnu!!!
•<=
/span>
•<=
/span>
•<=
/span>
•http://biol.lf1.cuni.cz/menu.htm
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Content-Location: file:///C:/E518CE38/POP208_soubory/master01.htm
Content-Transfer-Encoding: quoted-printable
Content-Type: text/html; charset="us-ascii"
<=
span
style=3D'font-family:Arial;color:yellow;mso-color-index:3'>–Errata v kapitole Populačn&iacu=
te;
genetika
<=
span
style=3D'font-family:Arial;color:yellow;mso-color-index:3'>–Diapozitivy z praktik<=
/div>
23
Klepnutím lze upravit styly předlohy textu
<=
/div>
Druhá úroveň
Třetí úroveň
Čtvrtá úroveň
Pátá úroveň
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známky![](3D"buttons.gif")
