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![](3D"slide0133_image001.gif")
2nd=
year, winter semester
3rd= week Octo= ber 21, 22 and 23, 2008
3rd= week Octo= ber 21, 22 and 23, 2008
=
P O P
U L A T I O N
=
G E N
E T I C S
=
II.
1
a) estimates of gene frequencies – different procedure of calculation at
vthree distinct phenot=
ypes
(e.g. in MN blood group system).
=
v
v
v
vcomplete dominance (Rh
blood group system, tasting of PTC or AR diseases)
2
![](3D"slide0065_image002.gif")
in the sample
individuals
all
number of
2
)
(
tes
of heterozygo
number
)
(
of homozygotes
number
2
+=
3;
=3D=
3;
Aa
AA
p
![](3D"slide0065_image003.gif")
b)
Selection
vagainst recessive
homozygotes (the dropping of frequency of recessive allele is inicially
rapide, then slowering, majority of deleterious alleles in heterozygotes, paradoxical result in an inappropriate applica=
tion
of the model)
vagainst both types=
of
homozygotes =3D selection favouring heterozygotes - conditions of equilibrium; while in=
CF
the selection mechanism against ca 2 % of dominant homozygotes is =
not clear (cholera epidemy
speculated about), in sickle-cell anemia in Africa the malaria i=
s functioning as the
selection factor.
3
S=
election
favouring heterozygotes -
Task 8/=
pp. 143-144
![](3D"slide0119_image005.gif")
![](3D"slide0119_image007.gif")
![](3D"slide0119_image009.gif")
![](3D"slide0119_image011.gif")
4
S=
election
favouring heterozygotes -
Task 8/=
pp. 143-144
Interpretation of =
c2 test:
incidence (observed frequencies) <=
span
style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-hansi-font-fami=
ly:
Arial;font-size:133%;color:yellow;mso-color-index:3'>of individual
genotypes and their (at C-H-W equilibrium) =
expected numbers a=
re
statistically significantly different – =
therefore, we may
suppose that this sample is in a balance =
elicited by mechan=
isms
other then C-H-W equilibrium.
![](3D"slide0122_image013.gif")
![](3D"slide0122_image015.gif")
5
b) Estimates of s1 a s2 selection coeficients<=
/b>
Reproductive abili=
ties
of individual genotypes
![](3D"slide0121_image016.gif")
Results of homework
III
![](3D"slide0121_image018.gif")
![](3D"slide0121_image020.gif")
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Population genetics 2
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Population genetics 2
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Population genetics 2
Equilibrium of
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Population genetics 2
– Task 9/p.146
Equilibrium of
mutations and selections II
![](3D"slide0124_image040.gif")
![](3D"slide0124_image042.gif")
![](3D"slide0124_image043.gif")
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Population genetics 2
Eq=
uilibrium
of mutations and selections III
![](3D"slide0125_image047.gif")
![](3D"slide0125_image049.gif")
![](3D"slide0125_image051.gif")
![](3D"slide0125_image052.gif")
![](3D"slide0125_image054.gif")
![](3D"slide0125_image056.gif")
![](3D"slide0125_image058.gif")
![](3D"slide0125_image060.gif")
![](3D"slide0125_image062.gif")
![](3D"slide0125_image063.gif")
![](3D"slide0125_image064.gif")
![](3D"slide0125_image065.gif")
![](3D"slide0125_image066.gif")
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Population genetics 2
![3D"MPj0177=](3D"slide0127_image067.jpg")
• 6 throws each t=
ime
– results of series mark in the table
• According to the
result (ratio, new frequencies) pA / =
qa change the rule=
s for
next series of throws (generation)
=
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Population genetics 2
Population genetics 2
s1 =3D 1 – w1 =3D 1 - 0.879 =3D 0.121
=
3;
s2 =3D 1 – w2 =3D 1 - 0.138 =3D 0.862
6
S=
election
favouring heterozygotes -
Task 8/=
pp. 143-144
s1 a s2 as additions of relati=
ve
reproductive abilities to 1
Adjustment to rela=
tive
reproductive ability by dividing with reproductive ability of most ferti=
le
genotype
Sickle-cell ana=
emia
as stable polymorphism by heterozygous advantage
Selection favouring
heterozygotes - Task 8/pp. 143-144
7
Errat=
a
<=
nobr>•p. 141, line 1 and 2 bot=
, in
formula
<=
nobr>•
<=
nobr>•p. 143, line 3 bot instead â place b
<=
nobr>•
<=
nobr>•p. 1=
45,
line 3 top instead í pla=
ce n
<=
nobr>•
<=
nobr>•p. 1=
47,
line 2 bot (question b)
replace <=
/span>their offspring by them
8
a) for AR mutant
alleles
Selection against
recessive homozygotes
9
Mutations
For rare diseases,=
q is too small, and
therefore
A
a
=
m
Equilibrium
Þ Þ Þ
a) for AR mutant a=
lleles
Estimation of muta=
tion
frequency m for albinism
10
Equilibrium
Þ Þ Þ
saa =3D 0.1
q2<=
span
style=3D'font-family:Arial;mso-ascii-font-family:Arial;mso-hansi-font-fami=
ly:
Arial;font-size:89%;color:yellow;mso-color-index:3;position:relative;
top:.37em;mso-text-raise:-25%'>equil. =3D 1/20 000
m =3D ???
Mutation =
;
Selection
A
a
m =
;
saa
a
b) for AD mutant a=
lleles
Selection against
dominant phenotype
11
for rare AD diseas=
es, p is small, and therefo=
re
Mutations
a
A
n
Equilibrium
Þ Þ Þ
S=
imple
model of gene drift I
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•mod=
elling of =
ra=
ndom use of alleles
(gametes)
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•random mechanism
– dice throw
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•small populatio=
n N =3D 3, and ori=
ginal p =3D q =3D &f=
rac12;
Drift – changes in gene frequencies in small <=
/b>populations eli=
cited
by random processes
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•allele A picked=
out
… side 1, 2 or 3 cast
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•allele a picked=
out
… side 4, 5 or 6 cast=
<=
span
style=3D'font-size:133%;color:yellow;mso-color-index:3'>•continue until =
one
allele fixed
12
Simple model of g=
ene
drift II
= – Task 14/p. 148
= – Task 14/p. 148
•Into your protocols, prepare this
table, at the least to the 10th generatio=
n
13
Simple model of ge=
ne
drift III
– Task 14/p. 148
– Task 14/p. 148
An
example of results after the firts series of throws and the change of t=
he
rules for next series
14
Simple model of ge=
ne
drift IV
– Task 14/p. 148
– Task 14/p. 148
An
example of results after the firts series of throws and the change of t=
he
rules for next series
15
-<=
/span> wor=
k in
pairs, one is throwing, the other is recording
- remind you the change of rules, w= here according to the r= esult the gene frequencies are changing for next series of throws and consequently which sides of t= he dice will represent the allele A or a
- continue in experiment until the point of fixation of one allele
- now, swap your roles, this way on= e pair will finish and evalua= te at least two experiments, each experiment and result visualize in a graph
- for whole classroom calculate ave= rage time of fixation as weighted mean of results of all partial experim= ents, the ratio of fixed A and a<= /i> alleles should be approx. 1 : 1
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- remind you the change of rules, w= here according to the r= esult the gene frequencies are changing for next series of throws and consequently which sides of t= he dice will represent the allele A or a
- continue in experiment until the point of fixation of one allele
- now, swap your roles, this way on= e pair will finish and evalua= te at least two experiments, each experiment and result visualize in a graph
- for whole classroom calculate ave= rage time of fixation as weighted mean of results of all partial experim= ents, the ratio of fixed A and a<= /i> alleles should be approx. 1 : 1
Simple model of gene drift IV
– Task 14/p. 148
– Task 14/p. 148
16
Simple model of =
gene
drift V – Task 14/p. 148
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Population genetics 2
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Population genetics 2
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Population genetics 2
Coefficients of inbreeding (F)
and of relations= hip (r)
![](3D"slide0087_image114.gif")
![](3D"slide0087_image115.gif")
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Population genetics 2
P=
opulation Frequency of Rh0
![](3D"slide0093_image117.gif")
![](3D"slide0093_image119.gif")
Caucasoid
(USA) ( p ) 0,03
<=
/div>
Negroid
(Africa) ( =
pi )
0,63
Negroid
(USA) ( pi´ ) 0,45
<=
/div>
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Population genetics 2
7. Conclusion
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------=_NextPart_01C945D9.5F8A2AC0
Content-Location: file:///C:/E518CE38/APOP208_soubory/script.js
Content-Transfer-Encoding: quoted-printable
Content-Type: application/javascript; charset="us-ascii"
function LoadSld()
{
var sld=3DGetObj("SlideObj")
if( !g_supportsPPTHTML ) {
sld.style.visibility=3D"visible"
return
}
if( MakeNotesVis() ) return
runAnimations =3D _InitAnimations();
if( IsWin("PPTSld") )
parent.SldUpdated(GetSldId())
g_origSz=3DparseInt(SlideObj.style.fontSize)
g_origH=3Dsld.style.posHeight
g_origW=3Dsld.style.posWidth
g_scaleHyperlinks=3D(document.all.tags("AREA").length>0)
if( g_scaleHyperlinks )
InitHLinkArray()
if( g_scaleInFrame||(IsWin("PPTSld") && parent.IsFullScrMode() ) )
document.body.scroll=3D"no"
_RSW()
if( IsWin("PPTSld") && parent.IsFullScrMode() )
FullScrInit();
=09
MakeSldVis();
ChkAutoAdv()
if( runAnimations )
{
if( document.all("NSPlay") )
document.all("NSPlay").autoStart =3D false;
if( sld.filters && sld.filters.revealtrans )
setTimeout( "document.body.start()", sld.filters.revealtrans.duration * =
1000 );
else
document.body.start();
}
}
function MakeSldVis()
{
var fTrans=3Dg_showAnimation && SldHasTrans()
if( fTrans )
{
if( g_bgSound ) {
idx=3Dg_bgSound.indexOf(",");
pptSound.src=3Dg_bgSound.substr( 0, idx );
pptSound.loop=3D -(parseInt(g_bgSound.substr(idx+1)));
}
SlideObj.filters.revealtrans.Apply()
}
SlideObj.style.visibility=3D"visible"
if( fTrans )
SlideObj.filters.revealtrans.Play()
}
function MakeNotesVis()
{
if( !IsNts() ) return false
SlideObj.style.display=3D"none"
nObj =3D document.all.item("NotesObj")
parent.SetHasNts(0)
if( nObj ) {
nObj.style.display=3D""
parent.SetHasNts(1)
}
return 1
}
function ChkAutoAdv()
{
if(SldHasTrans())
SlideObj.onfilterchange=3DAutoAdv
else
AutoAdv()
}
function AutoAdv()
{
if(!IsWin("PPTSld") || !gUseSldTimings )return
var sld=3DGetCurSld()
if( (sld.mAdvDelay>0) && !parent.IsFramesMode() )
setTimeout("parent.GoToNextSld()",sld.mAdvDelay)
}
function GetObj(id)
{
if(g_supportsPPTHTML) return document.all(id);
else return document.getElementById(id);
}
function SldHasTrans() { return SlideObj.style.filter !=3D ""; }
function GetSldId() { return sId=3Dlocation.href.substring(location.href.la=
stIndexOf('/')+1) }
function HideMenu() { if( frames["PPTSld"] && PPTSld.document.all.item("ctx=
tmenu") && PPTSld.ctxtmenu.style.display!=3D"none" ) { PPTSld.ctxtmenu.styl=
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function IsWin( name ) { return window.name =3D=3D name }
function IsNts() { return IsWin("PPTNts") }
function IsSldOrNts() { return( IsWin("PPTSld")||IsWin("PPTNts") ) }
function SupportsPPTAnimation() { return( navigator.platform =3D=3D "Win32"=
&& navigator.appVersion.indexOf("Windows")>0 ) }
function SupportsPPTHTML()
{
var appVer=3Dnavigator.appVersion, msie=3DappVer.indexOf("MSIE "), ver=3D0
if( msie >=3D 0 )
ver=3DparseFloat( appVer.substring( msie+5, appVer.indexOf(";",msie) ) )
else
ver=3DparseInt(appVer)
return( ver >=3D 4 && msie >=3D 0 )
}
function _RSW()
{
if( !g_supportsPPTHTML || IsNts() ||
( !g_scaleInFrame && (!IsWin("PPTSld") || !parent.IsFullScrMode()) ) )
return
var padding=3D0;
if( IsWin("PPTSld") && parent.IsFramesMode() ) padding=3D6
cltWidth=3Ddocument.body.clientWidth-padding
cltHeight=3Ddocument.body.clientHeight-padding
factor=3D(1.0*cltWidth)/g_origW
if( cltHeight < g_origH*factor )
factor=3D(1.0*cltHeight)/g_origH
newSize =3D g_origSz * factor
if( newSize < 1 ) newSize=3D1
s=3DSlideObj.style
s.fontSize=3DnewSize+"px"
s.posWidth=3Dg_origW*factor
s.posHeight=3Dg_origH*factor
s.posLeft=3D(cltWidth-s.posWidth+padding)/2
s.posTop=3D(cltHeight-s.posHeight+padding)/2
if( g_scaleHyperlinks )
ScaleHyperlinks( factor )
}
function _InitAnimations()
{
animRuntimeInstalled =3D ''+document.body.localTime !=3D 'undefined';
isFullScreen =3D (window.name =3D=3D "PPTSld") && !parent.IsFramesMode();
g_animUseRuntime =3D g_showAnimation && animRuntimeInstalled && !(isFullSc=
reen && parent.IsSldVisited());
if( g_animUseRuntime ) {
collSeq =3D document.all.tags("seq");
if( collSeq !=3D null ) {
for(ii=3D0;ii numSlds )
gSldJumpIdx =3D numSlds;
if ( gSldJumpIdx >=3D 0 ) {
if ( gSldJumpIdx =3D=3D 0 )
gSldJumpIdx =3D 1;
var jumpTo =3D parseInt(gSldJumpIdx);
gSldJump =3D 0; gSldJumpIdx =3D "";
win.GoToSld( parent.GetSldList().mList[jumpTo-1].mSldHref )
}
}
}
function _KDH()
{
if( event.keyCode =3D=3D 8 ) {
event.returnValue =3D 0;
parent.GoToPrevSld();
}
}
function DocumentOnClick()
{
if( IsNts() || parent.HideMenu() ) return;
if( ( g_allowAdvOnClick && (window.name=3D=3D"PPTSld") && !parent.IsFrames=
Mode() ) ||
(event && event.keyCode=3D=3D32) ) {
if( g_animUseRuntime && g_animMainSequence && g_animMainSequence.cangonex=
t )
return;
parent.GoToNextSld();
}
}
var g_supportsPPTHTML =3D SupportsPPTHTML(), g_scaleInFrame =3D 1, gId=3D""=
, g_bgSound=3D"",
g_scaleHyperlinks =3D false, g_allowAdvOnClick =3D 1, g_showInBrowser =
=3D 0, gLoopCont =3D 0, gUseSldTimings =3D 1;
var g_showAnimation =3D g_supportsPPTHTML && SupportsPPTAnimation() && ( (w=
indow.name=3D=3D"PPTSld" && !parent.IsFramesMode()) || g_showInBrowser );va=
r g_animManager =3D null;
var g_animUseRuntime =3D false;
var g_animItemsToHide, g_animInteractiveItems, g_animSlideTime;
var g_animMainSequence =3D null;
var ENDSHOW_MESG=3D"Konec prezentace, klepnutím ukončíte=
předvádění.", SCREEN_MODE=3D"Frames", gIsEndShow=
=3D0, NUM_VIS_SLDS=3D22, SCRIPT_HREF=3D"script.js", FULLSCR_HREF=3D"fullscr=
een.htm";
var gCurSld =3D gPrevSld =3D 1, g_offset =3D 0, gNtsOpen =3D gHasNts =3D gO=
tlTxtExp =3D 0, gHasNarration =3D 0, gOtlOpen =3D true
window.gPPTHTML=3DSupportsPPTHTML()
var gMainDoc=3Dnew Array(new hrefList("slide0133.htm",1,-1,1),new hrefList(=
"slide0065.htm",1,-1,1),new hrefList("slide0118.htm",1,-1,1),new hrefList("=
slide0119.htm",1,-1,1),new hrefList("slide0122.htm",1,-1,1),new hrefList("s=
lide0121.htm",1,-1,1),new hrefList("slide0069.htm",1,-1,1),new hrefList("sl=
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de0124.htm",1,-1,1),new hrefList("slide0125.htm",1,-1,1),new hrefList("slid=
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078.htm",1,-1,1),new hrefList("slide0130.htm",1,-1,1),new hrefList("slide01=
37.htm",1,-1,1),new hrefList("slide0132.htm",1,-1,1),new hrefList("slide008=
7.htm",1,-1,1),new hrefList("slide0093.htm",1,-1,1),new hrefList("slide0097=
.htm",1,-1,1));
function FullScrInit()
{
g_allowAdvOnClick =3D GetCurSld().mAdvOnClk
document.body.style.backgroundColor=3D"black"
document.oncontextmenu=3Dparent._CM;
document.onkeydown =3D _KDH;
document.ondragstart=3DCancel
document.onselectstart=3DCancel
self.focus()
}
function Redirect( frmId )
{
var str=3Ddocument.location.hash,idx=3Dstr.indexOf('#'), sId=3DGetSldId()
if(idx>=3D0) str=3Dstr.substr(1);
if( window.name !=3D frmId && ( sId !=3D str) ) {
obj =3D GetObj("Main-File")
window.location.href=3Dobj.href+"#"+sId
return 1
}
return 0
}
var MHTMLPrefix =3D CalculateMHTMLPrefix();
function CalculateMHTMLPrefix()
{
if ( document.location.protocol =3D=3D 'mhtml:') {
href=3Dnew String(document.location.href)
Start=3Dhref.indexOf('!')+1
End=3Dhref.lastIndexOf('/')+1
if (End < Start)
return href.substring(0, Start)
else
return href.substring(0, End)
}
return '';
}
function GetTags(base,tag)
{
if(g_supportsPPTHTML) return base.all.tags(tag);
else return base.getElementsByTagName(tag);
}
function UpdNtsPane(){ if(frames["PPTNts"]) PPTNts.location.replace( MHTMLP=
refix+GetHrefObj( gCurSld ).mNtsHref ) }
function UpdNavPane( sldIndex ){ if(gNavLoaded) PPTNav.UpdNav() }
function UpdOtNavPane(){ if(gOtlNavLoaded) PPTOtlNav.UpdOtlNav() }
function UpdOtlPane(){ if(gOtlLoaded) PPTOtl.UpdOtl() }
function SetHasNts( fVal )
{
if( gHasNts !=3D fVal ) {
gHasNts=3DfVal
UpdNavPane()
}
}
function ToggleOtlText()
{
gOtlTxtExp=3D!gOtlTxtExp
UpdOtlPane()
}
function ClearMedia()
{
if (PPTSld.pptSound) PPTSld.pptSound.loop =3D 0;
}
function FullScreen()
{
if ( PPTSld.g_animUseRuntime )
PPTSld.document.body.pause();
ClearMedia();
var href =3D ( document.location.protocol =3D=3D 'mhtml:') ? FULLSCR_HREF =
: FULLSCR_HREF+"#"+GetHrefObj(gCurSld).mSldHref;
if(PPTNav.event.ctrlKey) {
var w =3D (window.screen.availWidth * 1.0) / 2.0
var h =3D w * (PPTSld.g_origH * 1.0) / PPTSld.g_origW
win =3D window.open( MHTMLPrefix+href,null,"toolbar=3D0,resizable=3D1,top=
=3D0,left=3D0," + "width=3D"+ w + ",height=3D" + h );
if( win.document.body && PPTSld.g_animUseRuntime )
win.document.body.PPTSldFrameset=3Dwindow;
}
else
{
win =3D window.open( MHTMLPrefix+href,null,"fullscreen=3Dyes" );
if( win.document.body && PPTSld.g_animUseRuntime )
win.document.body.PPTSldFrameset=3Dwindow;
}
}
function ToggleVNarration()
{
rObj=3DPPTSld.document.all("NSPlay")
if( rObj && !PPTSld.g_animUseRuntime ) {
if( (rObj.playState =3D=3D 1)||(rObj.playState =3D=3D 0) )
rObj.Play()
else if( rObj.playState =3D=3D 2 )
rObj.Pause()
else
return;
}
else if( PPTSld.g_animUseRuntime )
{
narObj =3D PPTSld.document.all("narrationID")
if( narObj )
narObj.togglePause()
}
}
function GetCurSldNum()
{
obj=3DGetHrefObj(gCurSld)
if( obj.mOrigVis =3D=3D 1 )
return obj.mSldIdx
else
return gCurSld
}
function GetNumSlds()
{
if( GetHrefObj(gCurSld).mOrigVis =3D=3D 1 )
return GetSldList().mNumVisSlds;
else
return GetSldList().mList.length
}
function GetSldNum( href )
{
for(ii=3D0; ii 1 )
PopSldList();
else if( !IsFramesMode() ) {
if( gLoopCont )
GoToFirst()
else
EndShow()
}
}
function GoToPrevSld()
{
ii=3DgCurSld-1
if( ii > 0 ) {
obj=3DGetHrefObj(ii)
while ( obj && ( obj.mVis =3D=3D 0 ) && ( ii>0 ) )
obj=3DGetHrefObj(--ii)
if( ii =3D=3D 0 ) ii=3D1
GoToSldNum(ii)
}
}
function GoToFirst(){ GoToSld( GetHrefObj(1).mSldHref ) }
function GoToLast()
{
ii=3DGetSldList().mList.length
if( ii !=3D gCurSld )
GoToSld( GetHrefObj(ii).mSldHref )
}
function GoToSldNum( num )
{
if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue
obj =3D GetHrefObj( num )
obj.mVis=3D1
gPrevSld=3DgCurSld
gCurSld =3D num;
PPTSld.location.replace(MHTMLPrefix+obj.mSldHref)
if( IsFramesMode() ) {
UpdNavPane(); UpdOtlPane(); UpdNtsPane()
}
}
function GoToSld( href )
{
if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue
GetHrefObj( GetSldNum(href) ).mVis=3D1
PPTSld.location.replace(MHTMLPrefix+href)
}
function SldUpdated( id )
{
if( id =3D=3D GetHrefObj(gCurSld).mSldHref ) return
gPrevSld=3DgCurSld
gCurSld=3DGetSldNum(id)
if( IsFramesMode() ) {
UpdNavPane(); UpdOtlPane(); UpdNtsPane()
}
}
function PrevSldViewed(){ GoToSld( GetHrefObj(gPrevSld).mSldHref ) }
function HasPrevSld() { return ( gIsEndShow || ( gCurSld !=3D 1 && GetHrefO=
bj( gCurSld-1 ).mVis =3D=3D 1 )||( GetCurSldNum() > 1 ) ) }
function HasNextSld() { return (GetCurSldNum() !=3D GetNumSlds()) }
function CloseWindow() {
if( HideMenu() ) return;
var event =3D PPTSld.event;
if( !IsFramesMode() && event && (event.keyCode=3D=3D27 || event.keyCode=3D=
=3D32 || event.type=3D=3D"click" ) )
window.close( self );
CatchNumKeys( self, event );
}
function Unload() { gIsEndShow=3D0; }
function SetupEndShow() {
gIsEndShow=3D1;
PPTSld.document.body.scroll=3D"no";
PPTSld.document.onkeypress=3DCloseWindow;
PPTSld.document.onclick=3DCloseWindow;
PPTSld.document.oncontextmenu=3D_CM;
}
function EndShow()
{
if( IsFramesMode() ) return
if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue
doc=3DPPTSld.document
var dir =3D doc.body.dir
if( dir !=3D "rtl" ) dir =3D "ltr";
doc.open()
doc.writeln(' 0) {
PushSldList(sldList,fEnd);
gCurSld =3D 1;
}
else
if( PPTSld.event ) PPTSld.event.cancelBubble=3Dtrue
}
function PushSldList(arr,fEnd) {
var ii =3D gSldStack.length;
gSldStack[ii] =3D new SldList(arr,gCurSld,fEnd);
GoToSld( gSldStack[ii].mList[0].mSldHref );
}
function PopSldList() {
if (gSldStack[gSldStack.length-1].fEndShow)
EndShow()
else {
gCurSld =3D gSldStack[gSldStack.length-1].mCurSld;
gSldStack[gSldStack.length-1] =3D null;
gSldStack.length--;
var sldList =3D gSldStack[gSldStack.length-1];
GoToSld( sldList.mList[gCurSld - 1].mSldHref );
}
}
var custShowList=3Dnew Array();
function ImgBtn( oId,bId,w,action )
{
var t=3Dthis
t.Perform =3D _IBP
t.SetActive =3D _IBSetA
t.SetInactive=3D _IBSetI
t.SetPressed =3D _IBSetP
t.SetDisabled=3D _IBSetD
t.Enabled =3D _IBSetE
t.ChangeIcon =3D null
t.UserAction =3D action
t.ChgState =3D _IBUI
t.mObjId =3D oId
t.mBorderId=3D bId
t.mWidth =3D w
t.mIsOn =3D t.mCurState =3D 0
}
function _IBSetA()
{
if( this.mIsOn ) {
obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 )
obj.style.posTop=3D0
}
}
function _IBSetI()
{
if( this.mIsOn ) {
obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 )
obj.style.posTop=3D0
}
}
function _IBSetP()
{
if( this.mIsOn ) {
obj=3Dthis.ChgState( gShadowClr,gHiliteClr,2 )
obj.style.posLeft+=3D1; obj.style.posTop+=3D1
}
}
function _IBSetD()
{
obj=3Dthis.ChgState( gFaceClr,gFaceClr,0 )
obj.style.posTop=3D0
}
function _IBSetE( state )
{
var t=3Dthis
GetObj( t.mBorderId ).style.visibility=3D"visible"
if( state !=3D t.mIsOn ) {
t.mIsOn=3Dstate
if( state )
t.SetInactive()
else
t.SetDisabled()
}
}
function _IBP()
{
var t=3Dthis
if( t.mIsOn ) {
if( t.UserAction !=3D null )
t.UserAction()
if( t.ChangeIcon ) {
obj=3DGetObj(t.mObjId)
if( t.ChangeIcon() )
obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-4)*t.mWidth
else
obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-0)*t.mWidth
}
t.SetActive()
}
}
function _IBUI( clr1,clr2,nextState )
{
var t=3Dthis
SetBorder( GetObj( t.mBorderId ),clr1,clr2 )
obj=3DGetObj( t.mObjId )
obj.style.posLeft=3Dobj.style.posLeft+(t.mCurState-nextState)*t.mWidth-obj=
.style.posTop
t.mCurState=3DnextState
return obj
}
function TxtBtn( oId,oeId,action,chkState )
{
var t=3Dthis
t.Perform =3D _TBP
t.SetActive =3D _TBSetA
t.SetInactive=3D _TBSetI
t.SetPressed =3D _TBSetP
t.SetDisabled=3D _TBSetD
t.SetEnabled =3D _TBSetE
t.GetState =3D chkState
t.UserAction =3D action
t.ChgState =3D _TBUI
t.mObjId =3D oId
t.m_elementsId=3D oeId
t.mIsOn =3D 1
}
function _TBSetA()
{
var t=3Dthis
if( t.mIsOn && !t.GetState() )
t.ChgState( gHiliteClr,gShadowClr,0,0 )
}
function _TBSetI()
{
var t=3Dthis
if( t.mIsOn && !t.GetState() )
t.ChgState( gFaceClr,gFaceClr,0,0 )
}
function _TBSetP()
{
if( this.mIsOn )
this.ChgState( gShadowClr,gHiliteClr,1,1 )
}
function _TBSetD()
{
this.ChgState( gFaceClr,gFaceClr,0,0 )
this.mIsOn =3D 0
}
function _TBSetE()
{
var t=3Dthis
if( !t.GetState() )
t.ChgState( gFaceClr,gFaceClr,0,0 )
else
t.ChgState( gShadowClr,gHiliteClr,1,1 )
t.mIsOn =3D 1
}
function _TBP()
{
var t=3Dthis
if( t.mIsOn ) {
if( t.UserAction !=3D null )
t.UserAction()
if( !t.GetState )
return
if( t.GetState() )
t.SetPressed()
else
t.SetActive()
}
}
function _TBUI( clr1,clr2,lOffset,tOffset )
{
SetBorder( GetObj( this.mObjId ),clr1,clr2 )
Offset( GetObj( this.m_elementsId ),lOffset,tOffset )
}
function Offset( obj, top, left ){ obj.style.top=3Dtop; obj.style.left=3Dle=
ft }
function SetBorder( obj, upperLeft, lowerRight )
{
s=3Dobj.style;
s.borderStyle =3D "solid"
s.borderWidth =3D 1
s.borderLeftColor =3D s.borderTopColor =3D upperLeft
s.borderBottomColor=3D s.borderRightColor =3D lowerRight
}
function GetBtnObj(){ return gBtnArr[window.event.srcElement.id] }
function BtnOnOver(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetActive() }
function BtnOnDown(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetPressed() }
function BtnOnOut(){ b=3DGetBtnObj(); if( b !=3D null ) b.SetInactive() }
function BtnOnUp()
{
b=3DGetBtnObj()
if( b !=3D null )
b.Perform()
else
Upd()
}
function GetNtsState(){ return parent.gNtsOpen }
function GetOtlState(){ return parent.gOtlOpen }
function GetOtlTxtState(){ return parent.gOtlTxtExp }
function NtsBtnSetFlag( fVal )
{
s=3Ddocument.all.item( this.m_flagId ).style
s.display=3D"none"
if( fVal )
s.display=3D""
else
s.display=3D"none"
}
function _BSetA_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S=
etActive() }
function _BSetI_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S=
etInactive() }
function _BSetP_Border(){ b =3D gBtnArr[this.mObjId]; if( b !=3D null ) b.S=
etPressed() }
function _BSetA_BorderImg()
{
b =3D gBtnArr[this.mBorderId]
if( b !=3D null && this.mIsOn && !b.GetState() ) {
obj=3Dthis.ChgState( gHiliteClr,gShadowClr,2 )
obj.style.posTop=3D0
}
}
function _BSetI_BorderImg()
{
b =3D gBtnArr[this.mBorderId]
if( b !=3D null && this.mIsOn && !b.GetState() ) {
obj=3Dthis.ChgState( gFaceClr,gFaceClr,1 )
obj.style.posTop=3D0
}
}
var gHiliteClr=3D"THREEDHIGHLIGHT",gShadowClr=3D"THREEDSHADOW",gFaceClr=3D"=
THREEDFACE"
var gBtnArr =3D new Array()
gBtnArr["nb_otl"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOtlPan=
e,GetOtlState )
gBtnArr["nb_otlElem"] =3D new TxtBtn( "nb_otl","nb_otlElem",parent.ToggleOt=
lPane,GetOtlState )
gBtnArr["nb_nts"] =3D new ImgBtn( "nb_nts","nb_ntsBorder",10,parent.ToggleN=
tsPane )
gBtnArr["nb_nts"].SetActive =3D _BSetA_BorderImg;
gBtnArr["nb_nts"].SetInactive =3D _BSetI_BorderImg;
gBtnArr["nb_ntsBorder"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.=
ToggleNtsPane,GetNtsState )
gBtnArr["nb_ntsElem"] =3D new TxtBtn( "nb_ntsBorder","nb_ntsElem",parent.To=
ggleNtsPane,GetNtsState )
gBtnArr["nb_prevBorder"] =3D gBtnArr["nb_prev"]=3D new ImgBtn( "nb_prev","n=
b_prevBorder",30,parent.GoToPrevSld )
gBtnArr["nb_nextBorder"] =3D gBtnArr["nb_next"]=3D new ImgBtn( "nb_next","n=
b_nextBorder",30,parent.GoToNextSld )
gBtnArr["nb_sldshw"]=3D new ImgBtn( "nb_sldshw","nb_sldshwBorder",18,parent=
.FullScreen )
gBtnArr["nb_sldshwBorder"] =3D new TxtBtn( "nb_sldshw","nb_sldshwBorder",pa=
rent.FullScreen,null )
gBtnArr["nb_sldshwBorder"].SetActive =3D _BSetA_Border;
gBtnArr["nb_sldshwBorder"].SetInactive =3D _BSetI_Border;
gBtnArr["nb_sldshwText"] =3D new TxtBtn( "nb_sldshw","nb_sldshwText",parent=
.FullScreen,null )
gBtnArr["nb_sldshwText"].SetActive =3D _BSetA_Border;
gBtnArr["nb_sldshwText"].SetInactive =3D _BSetI_Border;
gBtnArr["nb_voice"] =3D gBtnArr["nb_voiceBorder"] =3D new ImgBtn( "nb_voice=
","nb_voiceBorder",18,parent.ToggleVNarration )
gBtnArr["nb_otlTxtBorder"] =3D gBtnArr["nb_otlTxt"]=3D new ImgBtn( "nb_otlT=
xt","nb_otlTxtBorder",23,parent.ToggleOtlText )
gBtnArr["nb_ntsBorder"].m_flagId=3D "nb_nts"
gBtnArr["nb_ntsBorder"].SetFlag =3D NtsBtnSetFlag
gBtnArr["nb_otlTxt"].ChangeIcon=3D GetOtlTxtState
var sNext=3D"Další",sPrev=3D"Předchozí",sEnd=3D"Kon=
ec prezentace",sFont=3D"Arial",sArrow=3D"Šipka",sFreeform=3D"Voln&yacu=
te; tvar",sRect=3D"Obdélník",sOval=3D"Ovál"
function ShowMenu()
{
BuildMenu();
var doc=3DPPTSld.document.body,x=3DPPTSld.event.clientX+doc.scrollLeft,y=
=3DPPTSld.event.clientY+doc.scrollTop
m =3D PPTSld.document.all.item("ctxtmenu")
m.style.pixelLeft=3Dx
if( (x+m.scrollWidth > doc.clientWidth)&&(x-m.scrollWidth > 0) )
m.style.pixelLeft=3Dx-m.scrollWidth
m.style.pixelTop=3Dy
if( (y+m.scrollHeight > doc.clientHeight)&&(y-m.scrollHeight > 0) )
m.style.pixelTop=3Dy-m.scrollHeight
m.style.display=3D""
}
function _CM()
{
if( !parent.IsFullScrMode() ) return;
if(!PPTSld.event.ctrlKey) {
ShowMenu()
return false
} else
HideMenu()
}
function BuildMenu()
{
if( PPTSld.document.all.item("ctxtmenu") ) return
var mObj=3DCreateItem( PPTSld.document.body )
mObj.id=3D"ctxtmenu"
mObj.style.visibility=3D"hidden"
var s=3DmObj.style
s.position=3D"absolute"
s.cursor=3D"default"
s.width=3D"120px"
SetCMBorder(mObj,"menu","black")
var iObj=3DCreateItem( mObj )
SetCMBorder( iObj, "threedhighlight","threedshadow" )
iObj.style.padding=3D2
CreateMenuItem( iObj,sNext,M_GoNextSld,M_True )
CreateMenuItem( iObj,sPrev,M_GoPrevSld,M_HasPrevSld )
CreateSeparator( iObj )
CreateMenuItem( iObj,sEnd,M_End,M_True )
mObj.style.visibility=3D"visible"
}
function Cancel() { window.event.cancelBubble=3Dtrue; window.event.returnVa=
lue=3Dfalse }
function Highlight() { ChangeClr("activecaption","threedhighlight") }
function Deselect() { ChangeClr("threedface","menutext") }
function Perform()
{
e=3DPPTSld.event.srcElement
if( e.type=3D=3D"menuitem" && e.IsActive() )
e.Action()
else
PPTSld.event.cancelBubble=3Dtrue
}
function ChangeClr( bg,clr )
{
e=3DPPTSld.event.srcElement
if( e.type=3D=3D"menuitem" && e.IsActive() ) {
e.style.backgroundColor=3Dbg
e.style.color=3Dclr
}
}
function M_HasPrevSld() { return( parent.HasPrevSld() ) }
function M_GoNextSld() { if( gIsEndShow ) M_End(); else GoToNextSld() }
function M_GoPrevSld() { if( gIsEndShow ) { gIsEndShow=3D0; history.back();=
PPTSld.event.cancelBubble=3Dtrue; } else GoToPrevSld() }
function M_True() { return true }
function M_End() { window.close( self ) }
function CreateMenuItem( node,text,action,eval )
{
var e=3DCreateItem( node )
e.type=3D"menuitem"
e.Action=3Daction
e.IsActive=3Deval
e.innerHTML=3Dtext
if( !e.IsActive() )
e.style.color=3D"threedshadow"
e.onclick=3DPerform
e.onmouseover=3DHighlight
e.onmouseout=3DDeselect
s=3De.style;
s.fontFamily=3DsFont
s.fontSize=3D"9pt"
s.paddingLeft=3D2
}
function CreateSeparator( node )
{
var sObj=3DCreateItem( node )
SetCMBorder(sObj,"menu","menu")
var s=3DsObj.style
s.borderTopColor=3D"threedshadow"
s.borderBottomColor=3D"threedhighlight"
s.height=3D1
s.fontSize=3D"0px"
}
function CreateItem( node )
{
var elem=3DPPTSld.document.createElement("DIV")
node.insertBefore( elem )
return elem
}
function SetCMBorder( o,ltClr,rbClr )
{
var s=3Do.style
s.backgroundColor=3D"menu"
s.borderStyle=3D"solid"
s.borderWidth=3D1
s.borderColor=3DltClr+" "+rbClr+" "+rbClr+" "+ltClr
}
------=_NextPart_01C945D9.5F8A2AC0
Content-Location: file:///C:/E518CE38/APOP208_soubory/fullscreen.htm
Content-Transfer-Encoding: quoted-printable
Content-Type: text/html; charset="us-ascii"
Population genetics 2
•Conclusion of experiments
<=
o:OLEObject
Type=3D"Embed" ProgID=3D"Excel.Sheet.8" ShapeID=3D"Object_x0020_0"
DrawAspect=3D"Content" ObjectID=3D"30">
![](3D"slide0130_image075.gif")
![](3D"slide0130_image076.gif")
17
Coefficient of inbreding
F
F
AB
CD
**
AC, AD
<=
/span>
BC, BD
A*
B*
C*
D*=
3;
AC, AD
<=
/span>
BC, BD
**
A*
B*
C*
D*=
3;
AA
BB
CC
DD
8x A*
8x B*
8x C*
8x D*
16x **=
3;
2x AB
2x AC
2x AD
2x BC
2x BD
2x CD
4x{=
3;
}60x=
18
Coefficient of relationship
r
r
AB
CD
**
AC, AD
<=
/span>
BC, BD
AC, AD
<=
/span>
BC, BD
**
19
and of relations= hip (r)
According to the ”motto” one (F)=
vs.
two genomes (r)
In the formula for r , the n
express the number of connecting lines in pedi=
gree
chart.
Task 12a, b, c/p. 147
20
b) r
for an half-uncle and his half-niece is 1/8
c) F
for an offspring of an half-uncle and his half-niece is 1/16=
Migration – Task 13/p. 148
21
•Home work: Tasks 10 =
and
11/p. 146 and 147
•<=
/span>
•Home study – t=
he
test will be next week!!!
22
Klepnutím lze upravit styly předlohy textu
<=
/div>
Druhá úroveň
Třetí úroveň
Čtvrtá úroveň
Pátá úroveň
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' + ENDSHOW_MESG + '
![](3D"notes_flag.gif")
Po=
známky![](3D"buttons.gif")
