Institute of Biology and Medical Genetics, laboratory of experimental genetics is inviting applicants for Ph.D. positions in molecular biology and genetics.

The mission of our group is to understand the molecular mechanisms of inherited monogenic and complex diseases using relevant animal models
The prospective thesis topics are:

• The role of Plzf (Promyelocytic leukemia zinc finger) in the pathogenesis of cardiovascular and metabolic disturbances in rat model strains
• Molecular biological aspects of the sperm head-tail coupling apparatus in normal and hd mutant rats
• Molecular mechanisms of limb malformation in centrobin and Plzf mutant rats
• Screening for genetic determinants of oligo/teratozoospermia in infertile men, informed by data from animal models

for further information please contact dr. František Liška frantisek.liska@lf1.cuni.cz

most relevant papers published by our group on the topics above

• Krupková, M., Janků, M., Liška, F., Šedová, L., Kazdová, L., Křenová, D., Křen, V., and Šeda, O. (2009). Pharmacogenetic model of retinoic acid-induced dyslipidemia and insulin resistance. Pharmacogenomics 10, 1915-1927. PubMed 19958091
• Liška, F., Šnajdr, P., Šedová, L., Šeda, O., Chylíková, B., Slámová, P., Krejčí, E., Sedmera, D., Grim, M., Křenová, D., and Křen, V. (2009). Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Dev Dyn 238, 673-684. PubMed 19191224
• Liška, F., Gösele, C., Rivkin, E., Tres, L., Cardoso, M.C., Domaing, P., Krejčí, E., Šnajdr, P., Lee-Kirsch, M.A., de Rooij, D.G., Křen, V., Křenová, D., Kierszenbaum, A.L., and Hübner, N. (2009). Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus. Biol Reprod 81, 1196-1205. PubMed 19710508
• Wang, Y., Liška, F., Gösele, C., Šedová, L., Křen, V., Křenová, D., Ivics, Z., Hübner, N., and Izsvák, Z. (2010). A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains. Genome Res 20, 19-27. PubMed 19887576

We offer:

• Modern molecular genetics laboratory
• Strong research network with close collaboration with research groups in Europe, USA and Canada
• the beautiful city of Prague

We require:

• M.Sc. or diploma degree in life sciences, natural sciences, medicine or bioinformatics
• fluent English (some Czech is welcome)

deadline for applications is April 24, 2011